The Effect of Chronic Lithium Administration on Dopamine Metabolism in Rat Striatum

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1978 Mar 1

PMID 25454

Citations 9

Authors

J E Hesketh

N M Nicolaou

G W Arbuthnott

A K Wright

Affiliations

Soon will be listed here.

Abstract

Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentration after 3 weeks of lithium administration. There was no change in tyrosine hydroxylase activity after 1, 2, and 3 weeks treatment. The results indicate an increase in the release and turnover of dopamine in the lithium-treated animals.

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