The TM6SF2 Variants, Novel Genetic Predictors for Nonalcoholic Steatohepatitis

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 2014 Dec 3

PMID 25451657

Citations 10

Authors

Yoon-Seok Roh

Rohit Loomba

Ekihiro Seki

Affiliations

Soon will be listed here.

Citing Articles

PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.

Rauff B, Alzahrani B, Chudhary S, Nasir B, Mahmood S, Bhinder M BMC Gastroenterol. 2022; 22(1):401.

PMID: 36028802 PMC: 9414345. DOI: 10.1186/s12876-022-02469-6.

Mechanism and therapeutic strategy of hepatic -deficient non-alcoholic fatty liver diseases and experiments.

Li Z, Wu G, Qiu C, Zhou Z, Wang Y, Song G World J Gastroenterol. 2022; 28(25):2937-2954.

PMID: 35978872 PMC: 9280743. DOI: 10.3748/wjg.v28.i25.2937.

The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C.

Oliveira A, Malta F, Zitelli P, Salles A, Gomes-Gouvea M, Nastri A BMC Gastroenterol. 2021; 21(1):81.

PMID: 33622266 PMC: 7901065. DOI: 10.1186/s12876-021-01654-3.

Nonalcoholic fatty liver disease and cardiovascular disease phenotypes.

Bisaccia G, Ricci F, Mantini C, Tana C, Luca Romani G, Schiavone C SAGE Open Med. 2020; 8:2050312120933804.

PMID: 32612827 PMC: 7307287. DOI: 10.1177/2050312120933804.

The Genetics of Clinical Liver Diseases: Insight into the E167K Variant.

Zhang X, Liu S, Dong Q, Xin Y, Xuan S J Clin Transl Hepatol. 2018; 6(3):326-331.

PMID: 30271746 PMC: 6160302. DOI: 10.14218/JCTH.2018.00022.

References

Kozlitina J, Smagris E, Stender S, Nordestgaard B, Zhou H, Tybjaerg-Hansen A . Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2014; 46(4):352-6. PMC: 3969786. DOI: 10.1038/ng.2901. View

Mahdessian H, Taxiarchis A, Popov S, Silveira A, Franco-Cereceda A, Hamsten A . TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc Natl Acad Sci U S A. 2014; 111(24):8913-8. PMC: 4066487. DOI: 10.1073/pnas.1323785111. View

Liu Y, Reeves H, Burt A, Tiniakos D, McPherson S, Leathart J . TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat Commun. 2014; 5:4309. PMC: 4279183. DOI: 10.1038/ncomms5309. View