Distal Deletion of Chromosome Ip in Ductal Carcinoma of the Breast

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1989 Jul 1

PMID 2545098

Citations 26

Authors

M Genuardi

H Tsihira

D E Anderson

G F Saunders

Affiliations

Soon will be listed here.

Abstract

By use of recombinant DNA probes that correspond to genetic loci residing on human chromosome 1, DNA samples from 37 ductal breast carcinomas and constitutional DNA from the same individuals were tested for loss of heterozygosity. A high frequency (41%) of reduction to homozygosity was detected with the probe p1-79, which recognizes the highly polymorphic locus D1Z2, localized on 1p36. Loss of heterozygosity at other chromosome 1 loci was much less common, not exceeding a frequency of 10%, and was never observed in the absence of the D1Z2 loss. Somatic loss of heterozygosity at D1Z2 was more frequent in patients with a strong family history of breast cancer (60%), in patients with early diagnosis (before 45 years of age) (70%), and in those with multiple tumors or tumor foci (50%) than in patients with none of the characteristics of hereditary tumors (21%). No associations were observed between loss of heterozygosity and prognostic factors. These results suggest that inactivation of a tumor suppressor gene located on the distal portion of chromosome 1p, alone or combined with other genetic changes, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast.

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References

Schwartz A, King M, Belle S, Satariano W, Swanson G . Risk of breast cancer to relatives of young breast cancer patients. J Natl Cancer Inst. 1985; 75(4):665-8. View

Darby J, Feder J, Selby M, Riccardi V, Ferrell R, Siao D . A discordant sibship analysis between beta-NGF and neurofibromatosis. Am J Hum Genet. 1985; 37(1):52-9. PMC: 1684550. View

Escot C, Theillet C, Lidereau R, Spyratos F, Champeme M, Gest J . Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas. Proc Natl Acad Sci U S A. 1986; 83(13):4834-8. PMC: 323837. DOI: 10.1073/pnas.83.13.4834. View

Lynch H, Lynch J . Breast cancer genetics in an oncology clinic: 328 consecutive patients. Cancer Genet Cytogenet. 1986; 22(4):369-71. DOI: 10.1016/0165-4608(86)90032-4. View

Friend S, Bernards R, Rogelj S, Weinberg R, Rapaport J, Albert D . A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 1986; 323(6089):643-6. DOI: 10.1038/323643a0. View

Fowler M, Nakai H, Byers M, Fukushima H, Eddy R, Henry W . Chromosome 1 localization of the human alpha-L-fucosidase structural gene with a homologous site on chromosome 2. Cytogenet Cell Genet. 1986; 43(1-2):103-8. DOI: 10.1159/000132304. View

Slamon D, Clark G, Wong S, Levin W, Ullrich A, McGuire W . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235(4785):177-82. DOI: 10.1126/science.3798106. View

Lee W, Bookstein R, Hong F, Young L, Shew J, Lee E . Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science. 1987; 235(4794):1394-9. DOI: 10.1126/science.3823889. View

Nakamura Y, Julier C, Wolff R, Holm T, OConnell P, Leppert M . Characterization of a human 'midisatellite' sequence. Nucleic Acids Res. 1987; 15(6):2537-47. PMC: 340667. DOI: 10.1093/nar/15.6.2537. View

10.

Jeffreys A, Wilson V, Kelly R, Taylor B, Bulfield G . Mouse DNA 'fingerprints': analysis of chromosome localization and germ-line stability of hypervariable loci in recombinant inbred strains. Nucleic Acids Res. 1987; 15(7):2823-36. PMC: 340701. DOI: 10.1093/nar/15.7.2823. View

11.

Lundberg C, Skoog L, Cavenee W, Nordenskjold M . Loss of heterozygosity in human ductal breast tumors indicates a recessive mutation on chromosome 13. Proc Natl Acad Sci U S A. 1987; 84(8):2372-6. PMC: 304653. DOI: 10.1073/pnas.84.8.2372. View

12.

Seizinger B, de la Monte S, Atkins L, Gusella J, Martuza R . Molecular genetic approach to human meningioma: loss of genes on chromosome 22. Proc Natl Acad Sci U S A. 1987; 84(15):5419-23. PMC: 298869. DOI: 10.1073/pnas.84.15.5419. View

13.

Fung Y, Murphree A, Tang A, Qian J, Hinrichs S, Benedict W . Structural evidence for the authenticity of the human retinoblastoma gene. Science. 1987; 236(4809):1657-61. DOI: 10.1126/science.2885916. View

14.

Mathew C, Smith B, Thorpe K, Wong Z, Royle N, Jeffreys A . Deletion of genes on chromosome 1 in endocrine neoplasia. Nature. 1987; 328(6130):524-6. DOI: 10.1038/328524a0. View

15.

Mathew C, Chin K, Easton D, Thorpe K, Carter C, Liou G . A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Nature. 1987; 328(6130):527-8. DOI: 10.1038/328527a0. View

16.

Simpson N, Kidd K, Goodfellow P, McDermid H, Myers S, Kidd J . Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Nature. 1987; 328(6130):528-30. DOI: 10.1038/328528a0. View

17.

Bodmer W, Bailey C, Bodmer J, Bussey H, Ellis A, Gorman P . Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature. 1987; 328(6131):614-6. DOI: 10.1038/328614a0. View

18.

Dao D, Schroeder W, CHAO L, Kikuchi H, Strong L, Riccardi V . Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor. Am J Hum Genet. 1987; 41(2):202-17. PMC: 1684225. View

19.

Rouleau G, Wertelecki W, Haines J, Hobbs W, Trofatter J, Seizinger B . Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature. 1987; 329(6136):246-8. DOI: 10.1038/329246a0. View

20.

Buroker N, Bestwick R, Haight G, Magenis R, Litt M . A hypervariable repeated sequence on human chromosome 1p36. Hum Genet. 1987; 77(2):175-81. DOI: 10.1007/BF00272388. View