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Folding and Stability of Integral Membrane Proteins in Amphipols

Overview
Publisher Elsevier
Specialties Biochemistry
Biophysics
Date 2014 Dec 3
PMID 25449655
Citations 23
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Abstract

Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have proven remarkably efficient at (i) stabilizing TMPs, as compared to detergent solutions, and (ii) folding them from a denatured state to a native, functional one. The underlying physical-chemical mechanisms are discussed.

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