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Hepatitis E As a Cause of Acute Jaundice Syndrome in Northern Uganda, 2010-2012

Overview
Journal Am J Trop Med Hyg
Specialty Tropical Medicine
Date 2014 Dec 3
PMID 25448237
Citations 21
Authors
Gemechu B Gerbi
Roxanne Williams
Barnabas Bakamutumaho
Stephen Liu
Robert Downing
Jan Drobeniuc
Saleem Kamili
Fujie Xu
Scott D Holmberg
Eyasu H Teshale
Affiliations
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Abstract

Hepatitis E virus (HEV) is a common cause of acute viral hepatitis in developing countries; however, its contribution to acute jaundice syndrome is not well-described. A large outbreak of hepatitis E occurred in northern Uganda from 2007 to 2009. In response to this outbreak, acute jaundice syndrome surveillance was established in 10 district healthcare facilities to determine the proportion of cases attributable to hepatitis E. Of 347 acute jaundice syndrome cases reported, the majority (42%) had hepatitis E followed by hepatitis B (14%), malaria (10%), hepatitis C (5%), and other/unknown (29%). Of hepatitis E cases, 72% occurred in Kaboong district, and 68% of these cases occurred between May and August of 2011. Residence in Kaabong district was independently associated with hepatitis E (adjusted odds ratio = 13; 95% confidence interval = 7-24). The findings from this surveillance show that an outbreak and sporadic transmission of hepatitis E occur in northern Uganda.

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