Low Serum 25-hydroxyvitamin D Concentrations Are Associated with Increased Risk for Melanoma and Unfavourable Prognosis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Dec 2

PMID 25437008

Citations 23

Authors

Benjamin Bade

Alexander Zdebik

Stefan Wagenpfeil

Stefan Graber

Jurgen Geisel

Thomas Vogt

Jorg Reichrath

Affiliations

Soon will be listed here.

Abstract

Background: Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.

Methods: Basal serum 25(OH)D concentrations were retrospectively analyzed in a cohort of melanoma patients (n = 324) and healthy controls (n = 141). We tested the hypothesis that serum 25(OH)D concentrations are predictive of melanoma risk, thickness of primary melanomas, and overall survival (OS).

Results: Median serum 25(OH)D concentrations were significantly lower (p = 0.004) in melanoma patients (median = 13.6 ng/ml) as compared to controls (median = 15.6 ng/ml). Primary tumors of patients with low serum 25(OH)D concentrations (<10 ng/ml) had significantly (p = 0.006) greater Breslow thickness (median: 1.9 mm) as compared to patients with higher levels (>20 ng/ml; median: 1.00 mm). Patients with 25(OH)D serum concentrations in the lowest quartile had inferior overall survival (median: 80 months) comparing with the highest quartile (median: 195 months; p = 0.049).

Conclusions: Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials.

Citing Articles

Malignant Melanoma: An Overview, New Perspectives, and Vitamin D Signaling.

Slominski R, Kim T, Janjetovic Z, Brozyna A, Podgorska E, Dixon K Cancers (Basel). 2024; 16(12).

PMID: 38927967 PMC: 11201527. DOI: 10.3390/cancers16122262.

Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes.

Ben-Eltriki M, Gayle E, Paras J, Nyame-Addo L, Chhabra M, Deb S Life (Basel). 2024; 14(4).

PMID: 38672780 PMC: 11050855. DOI: 10.3390/life14040510.

Editorial: Further advances in understanding the endocrine cancer microenvironment.

Coperchini F, Melillo R, Rotondi M Front Endocrinol (Lausanne). 2022; 13:1009963.

PMID: 36093100 PMC: 9449897. DOI: 10.3389/fendo.2022.1009963.

Low Vitamin D Status Predicts Poor Clinical Outcome in Advanced Melanoma Treated With Immune Checkpoint or BRAF/MEK Inhibitors: A Prospective Non-Interventional Side-by-Side Analysis.

Reichrath J, Biersack F, Wagenpfeil S, Schope J, Pfohler C, Saternus R Front Oncol. 2022; 12:839816.

PMID: 35669434 PMC: 9166268. DOI: 10.3389/fonc.2022.839816.

Cutaneous malignant melanoma incidence is strongly associated with European depigmented skin type regardless of ambient ultraviolet radiation levels: evidence from Worldwide population-based data.

You W, Henneberg R, Coventry B, Henneberg M AIMS Public Health. 2022; 9(2):378-402.

PMID: 35634021 PMC: 9114792. DOI: 10.3934/publichealth.2022026.

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