Engrailed Homeoproteins in Visual System Development

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2014 Nov 30

PMID 25432704

Citations 3

Authors

Andrea Wizenmann

Olivier Stettler

Kenneth L Moya

Affiliations

Soon will be listed here.

Abstract

Engrailed is a homeoprotein transcription factor. This family of transcription factors is characterized by their DNA-binding homeodomain and some members, including Engrailed, can transfer between cells and regulate protein translation in addition to gene transcription. Engrailed is intimately involved in the development of the vertebrate visual system. Early expression of Engrailed in dorsal mesencephalon contributes to the development and organization of a visual structure, the optic tectum/superior colliculus. This structure is an important target for retinal ganglion cell axons that carry visual information from the retina. Engrailed regulates the expression of Ephrin axon guidance cues in the tectum/superior colliculus. More recently it has been reported that Engrailed itself acts as an axon guidance cue in synergy with the Ephrin system and is proposed to enhance retinal topographic precision.

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