Cytoprotective Effects of Hydrogen Sulfide-releasing -methyl-D-aspartate Receptor Antagonists Are Mediated by Intracellular Sulfane Sulfur

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 Nov 29

PMID 25431645

Citations 15

Authors

Eizo Marutani

Masahiro Sakaguchi

Wei Chen

Kiyoshi Sasakura

Jifeng Liu

Ming Xian

Kenjiro Hanaoka

Tetsuo Nagano

Fumito Ichinose

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (HS) exerts a host of biological effects ranging from cytotoxicity to cytoprotection. Cytotoxicity of HS in neurodegenerative diseases may be mediated by -methyl-D-aspartate receptor (NMDAR) activation. To exploit cytoprotective effects of HS while minimizing its toxicity, we synthesized a series of HS-releasing NMDAR antagonists and examined their effects against 1-methyl-4-phenylpyridinium (MPP)-induced cell death, a cellular model of Parkinson's disease. We observed that cytoprotective effect of HS-releasing NMDAR antagonists correlated with their ability to increase intracellular sulfane sulfur, but not HS, levels. These studies suggest that HS-donor compounds that increase intracellular sulfane sulfur are potentially useful neuroprotective agents against neurodegenerative diseases.

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