Using SomaticSniper to Detect Somatic Single Nucleotide Variants
Overview
Affiliations
Detecting somatic single nucleotide variants (SNVs) is an essential component of cancer research with next generation sequencing data. This protocol describes how to run the SomaticSniper somatic SNV detector and then filter the output to eliminate most false positives. It also includes support protocols detailing the compilation of the software.
Branching clonal evolution patterns predominate mutational landscape in multiple myeloma.
Farswan A, Jena L, Kaur G, Gupta A, Gupta R, Rani L Am J Cancer Res. 2021; 11(11):5659-5679.
PMID: 34873486 PMC: 8640818.
Hoadley K, Siegel M, Kanchi K, Miller C, Ding L, Zhao W PLoS Med. 2016; 13(12):e1002174.
PMID: 27923045 PMC: 5140046. DOI: 10.1371/journal.pmed.1002174.