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The Novel Surfactant Protein SP-H Enhances the Phagocytosis Efficiency of Macrophage-like Cell Lines U937 and MH-S

Overview
Journal BMC Res Notes
Publisher Biomed Central
Specialties Biology
General Medicine
Date 2014 Nov 28
PMID 25427765
Citations 12
Authors
Ebru Diler
Martin Schicht
Andrea Rabung
Thomas Tschernig
Carola Meier
Felix Rausch
Fabian Garreis
Lars Brauer
Friedrich Paulsen
Affiliations
Soon will be listed here.
Abstract

Background: Surfactant proteins (SP) secreted by alveolar type 2 cells, play an essential role in maintaining the air-liquid barrier of the lung and are also involved in the opsonisation and clearance of bacteria by phagocytes. We have recently described a novel surfactant protein, SP-H (SFTA3). Expression of SP-H was earlier demonstrated to be upregulated by LPS and negatively regulated by IL-1β and IL-23 in vitro. The influence of SP-H on phagocytosis was measured using a murine and a human phagocytic cell line and fluorescent latex beads.

Findings: SP-H markedly increases phagocytosis in vitro in the murine-derived alveolar macrophage cell lines MH-S and in human-derived differentiated U937 cells.

Conclusion: It can be assumed that SP-H is involved in regulating phagocytic activity of macrophages. SP-H is a new player in pulmonary host defence.

Citing Articles

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The Potential Role of SP-G as Surface Tension Regulator in Tear Film: From Molecular Simulations to Experimental Observations.

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Deng Y, Angelova A Front Cell Dev Biol. 2021; 9:630242.

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Krause M, Hartig W, Mahr C, Richter C, Schob J, Puchta J Front Pediatr. 2020; 8:572851.

PMID: 33102410 PMC: 7546901. DOI: 10.3389/fped.2020.572851.

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