Predictors of Non-transplantation of Adult Donor Organs--an Observational Study Using Routine Data from Eurotransplant

Overview

Journal BMC Health Serv Res

Publisher Biomed Central

Specialty Health Services

Date 2014 Nov 26

PMID 25421753

Citations 2

Authors

Karl Philipp Drewitz

Martin Loss

Julika Loss

Christian Joachim Apfelbacher

Affiliations

Soon will be listed here.

Abstract

Background: The majority of pancreases, offered in allocation, are not transplanted. This pancreas under-utilisation is a phenomenon observed in all transplant systems in North-America and Europe. It was the aim of this study to analyse factors predictive of pancreas non-transplantation in Germany.

Methods: Routine Eurotransplant data of 3,666 deceased German donors (from 2002-2011) were used for multivariate modelling. Socio-demographic and medical factors were considered as independent variables in logistic regression models with non-transplantation as dependent variable.

Results: Male gender, advanced age, overweight/obesity, long ICU stay, a history of smoking, non-traumatic brain death, elevated levels of sodium, serum glucose, lipase/amylase and the liver not being considered for procurement were significant independent predictors of non-transplantation.

Conclusion: In line with previous research, advanced age, high BMI, long ICU stay and the liver not being considered for procurement were the strongest predictors of pancreas non-transplantation in Germany. About three quarters of the variance remained unexplained, suggesting that factors not assessed or unknown may play a decisive role.

Citing Articles

A Systematic Review of Donor Serum Sodium Level and Its Impact on Transplant Recipients.

Basmaji J, Hornby L, Rochwerg B, Luke P, Ball I Int J Organ Transplant Med. 2020; 11(2):43-54.

PMID: 32832039 PMC: 7430057.

Expanding pancreas donor pool by evaluation of unallocated organs after brain death: Study protocol clinical trial (SPIRIT Compliant).

Kulu Y, Khajeh E, Ghamarnejad O, Nikdad M, Sabagh M, Ali-Hasan-Al-Saegh S Medicine (Baltimore). 2020; 99(10):e19335.

PMID: 32150070 PMC: 7478640. DOI: 10.1097/MD.0000000000019335.

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