Glycerophosphate/Acylglycerophosphate Acyltransferases

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2014 Nov 22

PMID 25415055

Citations 49

Authors

Atsushi Yamashita

Yasuhiro Hayashi

Naoki Matsumoto

Yoko Nemoto-Sasaki

Saori Oka

Takashi Tanikawa

Takayuki Sugiura

Affiliations

Soon will be listed here.

Abstract

Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review.

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