The Direct Electrophilic Cyanation of β-keto Esters and Amides with Cyano Benziodoxole

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2014 Nov 20

PMID 25407817

Citations 6

Authors

Yao-Feng Wang

Jiashen Qiu

Dejie Kong

Yongtao Gao

Feipeng Lu

Pran Gopal Karmaker

Fu-Xue Chen

Affiliations

Soon will be listed here.

Abstract

The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.

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