Dietary Glutamate Supplementation Ameliorates Mycotoxin-induced Abnormalities in the Intestinal Structure and Expression of Amino Acid Transporters in Young Pigs

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Nov 19

PMID 25405987

Citations 26

Authors

Jielin Duan

Jie Yin

Miaomiao Wu

Peng Liao

Dun Deng

Gang Liu

Qingqi Wen

Yongfei Wang

Wei Qiu

Yan Liu

Xingli Wu

Wenkai Ren

Bie Tan

Minghong Chen

Hao Xiao

Li Wu

Tiejun Li

Charles M Nyachoti

Olayiwola Adeola

Yulong Yin

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate the hypothesis that dietary supplementation with glutamic acid has beneficial effects on growth performance, antioxidant system, intestinal morphology, serum amino acid profile and the gene expression of intestinal amino acid transporters in growing swine fed mold-contaminated feed. Fifteen pigs (Landrace×Large White) with a mean body weight (BW) of 55 kg were randomly divided into control group (basal feed), mycotoxin group (contaminated feed) and glutamate group (2% glutamate+contaminated feed). Compared with control group, mold-contaminated feed decreased average daily gain (ADG) and increased feed conversion rate (FCR). Meanwhile, fed mold-contaminated feed impaired anti-oxidative system and intestinal morphology, as well as modified the serum amino acid profile in growing pigs. However, supplementation with glutamate exhibited potential positive effects on growth performance of pigs fed mold-contaminated feed, ameliorated the imbalance antioxidant system and abnormalities of intestinal structure caused by mycotoxins. In addition, dietary glutamate supplementation to some extent restored changed serum amino acid profile caused by mold-contaminated feed. In conclusion, glutamic acid may be act as a nutritional regulating factor to ameliorate the adverse effects induced by mycotoxins.

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