A Negative Regulatory Element with Properties Similar to Those of Enhancers is Contained Within an Alu Sequence

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1989 Feb 1

PMID 2540418

Citations 27

Authors

J D Saffer

S J Thurston

Affiliations

Soon will be listed here.

Abstract

A negative regulatory element has been found within a member of the African green monkey Alu family of interspersed repeated sequences. This "reducer" element decreased transcription in both directions from a cellular simian virus 40-like bidirectional promoter independently of both orientation and position. The reducer was not promoter specific since it also decreased expression from the simian virus 40 early and human beta-globin promoters. In addition, the reducer decreased transcription from a polymerase III promoter. The reducer was contained in 38 base pairs of an Alu family member and interacted specifically with a monkey cell nuclear protein.

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