Seroprevalence of Celiac Disease Among United Arab Emirates Healthy Adult Nationals: a Gender Disparity

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2014 Nov 18

PMID 25400469

Citations 12

Authors

Yousif A Abu-Zeid

Waheeba S Jasem

Benjamin Lebwohl

Peter H Green

Gehad ElGhazali

Affiliations

Soon will be listed here.

Abstract

Aim: To determine celiac disease (CD) prevalence and associated manifestations or risk factors in healthy adult Emiratis.

Methods: It is a cross-sectional prospective study, recruiting 1197 (573 women and 624 men) healthy Emiratis between September 2007 and April 2008 among those who went to Al Ain Hospital to undertake the prenuptial examination. Test for anti-tissue transglutaminase (tTG) IgA antibodies was used for CD diagnosis. Subjects with positive results in the anti tTG antibodies assay were also tested for anti-endomysial (EMA) IgA antibodies. A structured interview was used to collect basic demographic and clinical recall data including: information on name, contact address, age, gender, education status, previous diagnosis of CD, diagnosis of CD in 1(st) degree relatives and history of "chronic diarrhea, anemia, headache, hepatitis, diabetes, tumor, and thyroid disorder".

Results: Fourteen blood samples (1.17%; 14/1197) were seropositive for CD. The latent CD seropositive patients were 13 women and 1 man and therefore the seroprevalence of CD was 1:86 (14/1197) for adult Emiratis: 1:44 (13/573) for women and 1:624 for men. Binary logistic regression revealed that history of chronic anemia (crude OR = 7.09; 95%CI: 2.32-21.61; P = 0.003) and being a woman (OR = 14.46; 95%CI: 1.89-110.91; P = 0.001) were associated with CD seropositivity. Whereas, the thyroid disorder showed a positive association with CD seropositivity that approach statistical significance (OR = 11.30; 95%CI: 1.32-96.95; P = 0.09) and therefore was included in the multiple logistic regression analysis, which showed that CD seropositivity is independently associated only with history of chronic anemia (OR = 4.58; 95%CI: 1.45-14.48; P = 0.01) and being a woman person (OR = 10.47; 95%CI: 1.33-82.14; P = 0.026).

Conclusion: Compared to men the CD seroprevalence among women was remarkably higher. The CD association with women and chronic anemia is of importance from a public health perspective.

Citing Articles

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References

Vazquez H, Smecuol E, Flores D, Mazure R, Pedreira S, Niveloni S . Relation between cigarette smoking and celiac disease: evidence from a case-control study. Am J Gastroenterol. 2001; 96(3):798-802. DOI: 10.1111/j.1572-0241.2001.03625.x. View

Dixit R, Lebwohl B, Ludvigsson J, Lewis S, Rizkalla-Reilly N, Green P . Celiac disease is diagnosed less frequently in young adult males. Dig Dis Sci. 2014; 59(7):1509-12. DOI: 10.1007/s10620-014-3025-6. View

Guandalini S, Gupta P . Do you still need a biopsy to diagnose celiac disease?. Curr Gastroenterol Rep. 2001; 3(5):385-91. DOI: 10.1007/s11894-001-0080-x. View

Gomez J, Selvaggio G, Viola M, Pizarro B, La Motta G, de Barrio S . Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area. Am J Gastroenterol. 2001; 96(9):2700-4. DOI: 10.1111/j.1572-0241.2001.04124.x. View

Rutz R, Ritzler E, Fierz W, Herzog D . Prevalence of asymptomatic celiac disease in adolescents of eastern Switzerland. Swiss Med Wkly. 2002; 132(3-4):43-7. DOI: 10.4414/smw.2002.09793. View

Howard M, Turnbull A, Morley P, Hollier P, Webb R, Clarke A . A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. J Clin Pathol. 2002; 55(10):754-7. PMC: 1769776. DOI: 10.1136/jcp.55.10.754. View

Ciclitira P, Moodie S . Transition of care between paediatric and adult gastroenterology. Coeliac disease. Best Pract Res Clin Gastroenterol. 2003; 17(2):181-95. DOI: 10.1016/s1521-6918(02)00147-6. View

Accomando S, Cataldo F . The global village of celiac disease. Dig Liver Dis. 2004; 36(7):492-8. DOI: 10.1016/j.dld.2004.01.026. View

Rostami K, Malekzadeh R, Shahbazkhani B, Akbari M, Catassi C . Coeliac disease in Middle Eastern countries: a challenge for the evolutionary history of this complex disorder?. Dig Liver Dis. 2004; 36(10):694-7. DOI: 10.1016/j.dld.2004.05.010. View

10.

Ivarsson A, Persson L, Juto P, Peltonen M, Suhr O, Hernell O . High prevalence of undiagnosed coeliac disease in adults: a Swedish population-based study. J Intern Med. 1999; 245(1):63-8. DOI: 10.1046/j.1365-2796.1999.00403.x. View

11.

Guandalini S, Guiadalini S, Kelly C . Toward optimal health: Stefano Guandalini [corrected] M.D., and Ciaran P. Kelly, M.D. Discuss celiac disease. Interview by Jodi R Godfrey. J Womens Health (Larchmt). 2005; 14(2):110-6. DOI: 10.1089/jwh.2005.14.110. View

12.

Mulder C, Cellier C . Coeliac disease: changing views. Best Pract Res Clin Gastroenterol. 2005; 19(3):313-21. DOI: 10.1016/j.bpg.2005.01.006. View

13.

Green P, Rostami K, Marsh M . Diagnosis of coeliac disease. Best Pract Res Clin Gastroenterol. 2005; 19(3):389-400. DOI: 10.1016/j.bpg.2005.02.006. View

14.

Ivarsson A . The Swedish epidemic of coeliac disease explored using an epidemiological approach--some lessons to be learnt. Best Pract Res Clin Gastroenterol. 2005; 19(3):425-40. DOI: 10.1016/j.bpg.2005.02.005. View

15.

Verkasalo M, Raitakari O, Viikari J, Marniemi J, Savilahti E . Undiagnosed silent coeliac disease: a risk for underachievement?. Scand J Gastroenterol. 2005; 40(12):1407-12. DOI: 10.1080/00365520510023792. View

16.

Abenavoli L, Proietti I, Leggio L, Ferrulli A, Vonghia L, Capizzi R . Cutaneous manifestations in celiac disease. World J Gastroenterol. 2006; 12(6):843-52. PMC: 4066147. DOI: 10.3748/wjg.v12.i6.843. View

17.

Holtmeier W, Caspary W . Celiac disease. Orphanet J Rare Dis. 2006; 1:3. PMC: 1435993. DOI: 10.1186/1750-1172-1-3. View

18.

Niewinski M . Advances in celiac disease and gluten-free diet. J Am Diet Assoc. 2008; 108(4):661-72. DOI: 10.1016/j.jada.2008.01.011. View

19.

Addolorato G, Leggio L, dAngelo C, Mirijello A, Ferrulli A, Cardone S . Affective and psychiatric disorders in celiac disease. Dig Dis. 2008; 26(2):140-8. DOI: 10.1159/000116772. View

20.

Fasano A . Should we screen for coeliac disease? Yes. BMJ. 2009; 339:b3592. DOI: 10.1136/bmj.b3592. View