Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2014 Nov 18

PMID 25399848

Citations 11

Authors

Nasimudeen R Jabir

Chelapram K Firoz

Saleh S Baeesa

Ghulam Md Ashraf

Suhail Akhtar

Warda Kamal

Mohammad A Kamal

Shams Tabrez

Affiliations

Soon will be listed here.

Abstract

Neurodegeneration is the progressive loss of neuronal structure and function, which ultimately leads to neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis, and Huntington's disease. Even after the recent significant advances in neurobiology, the above-mentioned disorders continue to haunt the global population. Several studies have suggested the role of specific environmental and genetic risk factors associated with these disorders. However, the exact mechanism associated with the progression of these disorders still needs to be elucidated. In the recent years, sophisticated research has revealed interesting association of prominent neurodegenerative disorders such as AD and PD with chronic diseases such as cancer, diabetes, and cardiovascular diseases. Several common molecular mechanisms such as generation of free radicals, oxidative DNA damage, aberrations in mitochondrial DNA, and dysregulation of apoptosis have been highlighted as possible points of connection. The present review summarizes the possible mechanism of coexistence of AD and PD with other chronic diseases.

Citing Articles

Causal relationship between Alzheimer's disease and cardiovascular disease: a bidirectional Mendelian randomization analysis.

Zhang F, Xian D, Feng J, Ning L, Jiang T, Xu W Aging (Albany NY). 2023; 15(17):9022-9040.

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Correlation between serum IGF-1 and EGF levels and neuropsychiatric and cognitive in Parkinson's disease patients.

Shi X, Zheng J, Ma J, Li D, Gu Q, Chen S Neurol Sci. 2022; 44(3):881-887.

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Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and Cardiovascular Disease.

Wang K, Lu Y, Morrow D, Xiao D, Xu C J Mol Neurosci. 2022; 72(5):1085-1097.

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Coenzyme Q Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases.

Gutierrez-Mariscal F, Arenas-de Larriva A, Limia-Perez L, Romero-Cabrera J, Yubero-Serrano E, Lopez-Miranda J Int J Mol Sci. 2020; 21(21).

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Development of early diagnosis of Parkinson's disease: Illusion or reality?.

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References

Ottaviani G, Lavezzi A, Rossi L, Matturri L . Proliferating cell nuclear antigen (PCNA) and apoptosis in hyperacute and acute myocardial infarction. Eur J Histochem. 1999; 43(1):7-14. View

Raina A, Monteiro M, McShea A, Smith M . The role of cell cycle-mediated events in Alzheimer's disease. Int J Exp Pathol. 1999; 80(2):71-6. PMC: 2517757. DOI: 10.1046/j.1365-2613.1999.00106.x. View

Dhalla N, Temsah R, Netticadan T . Role of oxidative stress in cardiovascular diseases. J Hypertens. 2000; 18(6):655-73. DOI: 10.1097/00004872-200018060-00002. View

Raina A, Zhu X, Rottkamp C, Monteiro M, Takeda A, Smith M . Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res. 2000; 61(2):128-33. DOI: 10.1002/1097-4547(20000715)61:2<128::AID-JNR2>3.0.CO;2-H. View

Cai H, Harrison D . Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000; 87(10):840-4. DOI: 10.1161/01.res.87.10.840. View

Shimohama S . Apoptosis in Alzheimer's disease--an update. Apoptosis. 2001; 5(1):9-16. DOI: 10.1023/a:1009625323388. View

Rosen P, Nawroth P, King G, Moller W, Tritschler H, Packer L . The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev. 2001; 17(3):189-212. DOI: 10.1002/dmrr.196. View

Scheubel R, Bartling B, Simm A, Silber R, Drogaris K, Darmer D . Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival?. J Am Coll Cardiol. 2002; 39(3):481-8. DOI: 10.1016/s0735-1097(01)01769-7. View

Doraiswamy P, Leon J, Cummings J, Marin D, Neumann P . Prevalence and impact of medical comorbidity in Alzheimer's disease. J Gerontol A Biol Sci Med Sci. 2002; 57(3):M173-7. DOI: 10.1093/gerona/57.3.m173. View

10.

Reid M, Durham W . Generation of reactive oxygen and nitrogen species in contracting skeletal muscle: potential impact on aging. Ann N Y Acad Sci. 2002; 959:108-16. DOI: 10.1111/j.1749-6632.2002.tb02087.x. View

11.

Senderowicz A . The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01. Oncologist. 2002; 7 Suppl 3:12-9. DOI: 10.1634/theoncologist.7-suppl_3-12. View

12.

Carro E, Trejo J, Gomez-Isla T, LeRoith D, Torres-Aleman I . Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med. 2002; 8(12):1390-7. DOI: 10.1038/nm1202-793. View

13.

Evans J, Goldfine I, Maddux B, Grodsky G . Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?. Diabetes. 2002; 52(1):1-8. DOI: 10.2337/diabetes.52.1.1. View

14.

Tatton W, Chalmers-Redman R, Brown D, Tatton N . Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann Neurol. 2003; 53 Suppl 3:S61-70; discussion S70-2. DOI: 10.1002/ana.10489. View

15.

Friedlander R . Apoptosis and caspases in neurodegenerative diseases. N Engl J Med. 2003; 348(14):1365-75. DOI: 10.1056/NEJMra022366. View

16.

Ogawa O, Zhu X, Lee H, Raina A, Obrenovich M, Bowser R . Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?. Acta Neuropathol. 2003; 105(5):524-8. DOI: 10.1007/s00401-003-0684-3. View

17.

Bachman D, Green R, Benke K, Cupples L, Farrer L . Comparison of Alzheimer's disease risk factors in white and African American families. Neurology. 2003; 60(8):1372-4. DOI: 10.1212/01.wnl.0000058751.43033.4d. View

18.

Cooke M, Evans M, Dizdaroglu M, Lunec J . Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 2003; 17(10):1195-214. DOI: 10.1096/fj.02-0752rev. View

19.

Ogawa O, Lee H, Zhu X, Raina A, Harris P, Castellani R . Increased p27, an essential component of cell cycle control, in Alzheimer's disease. Aging Cell. 2003; 2(2):105-10. DOI: 10.1046/j.1474-9728.2003.00042.x. View

20.

Kukreja R, Hess M . The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res. 1992; 26(7):641-55. DOI: 10.1093/cvr/26.7.641. View