The Glioblastoma Vasculature As a Target for Cancer Therapy

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2014 Nov 18

PMID 25399584

Citations 27

Authors

Anna Dimberg

Affiliations

Soon will be listed here.

Abstract

Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.

Citing Articles

Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme: a systematic review going beyond pathologic implications.

Vageli D, Doukas P, Goupou K, Benos A, Astara K, Zacharouli K Oncol Res. 2024; 32(8):1239-1256.

PMID: 39055895 PMC: 11267112. DOI: 10.32604/or.2024.052130.

Unlocking Bevacizumab's Potential: rCBV as a Predictive Biomarker for Enhanced Survival in Glioblastoma IDH-Wildtype Patients.

Alvarez-Torres M, Balana C, Fuster-Garcia E, Puig J, Garcia-Gomez J Cancers (Basel). 2024; 16(1).

PMID: 38201588 PMC: 10778147. DOI: 10.3390/cancers16010161.

Glioblastoma vaccines: past, present, and opportunities.

Xiong Z, Raphael I, Olin M, Okada H, Li X, Kohanbash G EBioMedicine. 2024; 100:104963.

PMID: 38183840 PMC: 10808938. DOI: 10.1016/j.ebiom.2023.104963.

Engineering the glioblastoma microenvironment with bioactive nanoparticles for effective immunotherapy.

Blanchard R, Adjei I RSC Adv. 2023; 13(45):31411-31425.

PMID: 37901257 PMC: 10603567. DOI: 10.1039/d3ra01153d.

Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma.

Tang J, Li Y, Liu B, Liang W, Hu S, Shi M Pathol Oncol Res. 2021; 27:1609997.

PMID: 34867089 PMC: 8641556. DOI: 10.3389/pore.2021.1609997.