Genome Sequence of the Anterograde-Spread-Defective Herpes Simplex Virus 1 Strain MacIntyre
Overview
Affiliations
We used paired-end Illumina deep sequencing and de novo assembly to determine the genome sequence of herpes simplex virus 1 (HSV-1) strain MacIntyre (aka McIntyre). The MacIntyre strain originated from the brain of a patient with lethal HSV encephalitis and has a unique limitation in its neuronal spread, moving solely in the retrograde direction.
Bergeman M, Hernandez M, Diefenderfer J, Drewes J, Velarde K, Tierney W J Virol. 2024; 98(2):e0178523.
PMID: 38193690 PMC: 10883806. DOI: 10.1128/jvi.01785-23.
LIVE-CELL FLUORESCENCE MICROSCOPY OF HSV-1 CELLULAR EGRESS BY EXOCYTOSIS.
Bergeman M, Hernandez M, Diefenderfer J, Drewes J, Velarde K, Tierney W bioRxiv. 2023; .
PMID: 36909512 PMC: 10002666. DOI: 10.1101/2023.02.27.530373.
Eyeblink tract tracing with two strains of herpes simplex virus 1.
ODell D, Smith-Bell C, Enquist L, Engel E, Schreurs B Brain Res. 2022; 1793:148040.
PMID: 35932812 PMC: 10245079. DOI: 10.1016/j.brainres.2022.148040.
Tierney W, Vicino I, Sun S, Chiu W, Engel E, Taylor M Methods Mol Biol. 2022; 2431:181-206.
PMID: 35412277 PMC: 10427112. DOI: 10.1007/978-1-0716-1990-2_9.
LoReTTA, a user-friendly tool for assembling viral genomes from PacBio sequence data.
Al Qaffas A, Nichols J, Davison A, Ourahmane A, Hertel L, McVoy M Virus Evol. 2021; 7(1):veab042.
PMID: 33996146 PMC: 8111061. DOI: 10.1093/ve/veab042.