Low HDL Cholesterol is Correlated to the Acute Ischemic Stroke with Diabetes Mellitus

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2014 Nov 15

PMID 25395241

Citations 9

Authors

Yun Luo

Jingwei Li

Junfeng Zhang

Yun Xu

Affiliations

Soon will be listed here.

Abstract

Background: To clarify the role of lipid composition in the occurrence of acute ischemic stroke (AIS) with diabetes mellitus (DM) and its influence factors.

Methods: Data was collected from the patients hospitalization in Affiliated Drum Tower Hospital of Nanjing University Medical School from October 2008 to May 2012, which included AIS and non-AIS consist of transient ischemic attack (TIA) and Vertigo or dizzy. Lipid and other risk factors including blood glucose (BG), uric acid (UA), hypertension, DM and atrial fibrillation (AF) were investigated in relation to occurrence of AIS.

Results: The level of high density lipoprotein (HDL) cholesterol was decreased obviously in the DM group compared to the non-DM group and low level of HDL cholesterol was prevalent in the AIS patients with DM. logistic regression demonstrated that decreased HDL cholesterol was correlated to the AIS with DM, not all AIS, and the relative risk of ischemic stroke in low HDL cholesterol level group was 2.113 (95% CI = 1.191-3.749, P = 0.011) compared to the high level group. Furthermore, age has the obviously impact on it. HDL cholesterol was correlated to the AIS with DM just in the populations of aged ≦70 years (OR = 0.192, P = 0.000), low level of HDL cholesterol had more high risk of ischemic stroke than that in the high level group (OR = 6.818, P = 0.002).

Conclusion: Decreased HDL cholesterol was correlated to the occurrence of AIS with DM, especially in the populations of aged ≦70 years.

Citing Articles

In Mild and Moderate Acute Ischemic Stroke, Increased Lipid Peroxidation and Lowered Antioxidant Defenses Are Strongly Associated with Disabilities and Final Stroke Core Volume.

Maes M, Brinholi F, Michelin A, Matsumoto A, de Oliveira Semeao L, Almulla A Antioxidants (Basel). 2023; 12(1).

PMID: 36671047 PMC: 9854933. DOI: 10.3390/antiox12010188.

Inverse Association between High-Density Lipoprotein Cholesterol and Adverse Outcomes among Acute Ischemic Stroke Patients with Diabetes Mellitus.

Hu G, Pan Y, Wang M, Meng X, Jiang Y, Li Z Biomedicines. 2021; 9(12).

PMID: 34944763 PMC: 8698640. DOI: 10.3390/biomedicines9121947.

A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults.

Tang F, Wang J, Nicholas S, Qian D, Liu R Lipids Health Dis. 2021; 20(1):20.

PMID: 33618731 PMC: 7898430. DOI: 10.1186/s12944-021-01449-1.

Relationship between lipoproteins, thrombosis, and atrial fibrillation.

Ding W, Protty M, Davies I, Lip G Cardiovasc Res. 2021; 118(3):716-731.

PMID: 33483737 PMC: 8859639. DOI: 10.1093/cvr/cvab017.

Immune-inflammatory, oxidative stress and biochemical biomarkers predict short-term acute ischemic stroke death.

Reiche E, Gelinksi J, Alfieri D, Flauzino T, Lehmann M, de Araujo M Metab Brain Dis. 2019; 34(3):789-804.

PMID: 30875023 DOI: 10.1007/s11011-019-00403-6.

References

Zhang Y, Tuomilehto J, Jousilahti P, Wang Y, Antikainen R, Hu G . Total and high-density lipoprotein cholesterol and stroke risk. Stroke. 2012; 43(7):1768-74. DOI: 10.1161/STROKEAHA.111.646778. View

Goldstein L, Bushnell C, Adams R, Appel L, Braun L, Chaturvedi S . Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2010; 42(2):517-84. DOI: 10.1161/STR.0b013e3181fcb238. View

Calvert G, Graham J, Mannik T, Wise P, Yeates R . Effects of therapy on plasma-high-density-lipoprotein-cholesterol concentration in diabetes mellitus. Lancet. 1978; 2(8080):66-8. DOI: 10.1016/s0140-6736(78)91380-6. View

Bowman T, Sesso H, Ma J, Kurth T, Kase C, Stampfer M . Cholesterol and the risk of ischemic stroke. Stroke. 2003; 34(12):2930-4. DOI: 10.1161/01.STR.0000102171.91292.DC. View

Amarenco P, Labreuche J, Touboul P . High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: a systematic review. Atherosclerosis. 2007; 196(2):489-96. DOI: 10.1016/j.atherosclerosis.2007.07.033. View

Kurth T, Everett B, Buring J, Kase C, Ridker P, Gaziano J . Lipid levels and the risk of ischemic stroke in women. Neurology. 2007; 68(8):556-62. PMC: 1805634. DOI: 10.1212/01.wnl.0000254472.41810.0d. View

Kennedy A, Lappin T, Lavery T, Hadden D, Weaver J, Montgomery D . Relation of high-density lipoprotein cholesterol concentration to type of diabetes and its control. Br Med J. 1978; 2(6146):1191-4. PMC: 1608370. DOI: 10.1136/bmj.2.6146.1191. View

Mooradian A . Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab. 2009; 5(3):150-9. DOI: 10.1038/ncpendmet1066. View

Barter P . High density lipoprotein: a therapeutic target in type 2 diabetes. Endocrinol Metab (Seoul). 2014; 28(3):169-77. PMC: 3811694. DOI: 10.3803/EnM.2013.28.3.169. View

10.

Turnbull F, Abraira C, Anderson R, Byington R, Chalmers J, Duckworth W . Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia. 2009; 52(11):2288-98. DOI: 10.1007/s00125-009-1470-0. View

11.

Uddin M, Alam B, Jabbar M, Mohammad Q, Ahmed S . Association of lipid profile with ischemic stroke. Mymensingh Med J. 2009; 18(2):131-5. View

12.

Mattila T, de Boer A . Influence of intensive versus conventional glucose control on microvascular and macrovascular complications in type 1 and 2 diabetes mellitus. Drugs. 2010; 70(17):2229-45. DOI: 10.2165/11585220-000000000-00000. View

13.

Woodward M, Barzi F, Feigin V, Gu D, Huxley R, Nakamura K . Associations between high-density lipoprotein cholesterol and both stroke and coronary heart disease in the Asia Pacific region. Eur Heart J. 2007; 28(21):2653-60. DOI: 10.1093/eurheartj/ehm427. View

14.

Lisak M, Demarin V, Trkanjec Z, Basic-Kes V . Hypertriglyceridemia as a possible independent risk factor for stroke. Acta Clin Croat. 2014; 52(4):458-63. View

15.

Beckman J, Creager M, Libby P . Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA. 2002; 287(19):2570-81. DOI: 10.1001/jama.287.19.2570. View

16.

Koren-Morag N, Tanne D, Graff E, Goldbourt U . Low- and high-density lipoprotein cholesterol and ischemic cerebrovascular disease: the bezafibrate infarction prevention registry. Arch Intern Med. 2002; 162(9):993-9. DOI: 10.1001/archinte.162.9.993. View

17.

Hewitt J, Castilla Guerra L, Fernandez-Moreno M, Sierra C . Diabetes and stroke prevention: a review. Stroke Res Treat. 2013; 2012:673187. PMC: 3543806. DOI: 10.1155/2012/673187. View

18.

Newman-Toker D, Kerber K, Hsieh Y, Pula J, Omron R, Saber Tehrani A . HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness. Acad Emerg Med. 2013; 20(10):986-96. DOI: 10.1111/acem.12223. View

19.

Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H . Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages. Diabetes Care. 2009; 32(7):1221-3. PMC: 2699721. DOI: 10.2337/dc08-1677. View

20.

Yu X, Fu Y, Zhang D, Yin K, Tang C . Foam cells in atherosclerosis. Clin Chim Acta. 2013; 424:245-52. DOI: 10.1016/j.cca.2013.06.006. View