Multiple Steps Are Required for the Induction of Tumors by Abelson Murine Leukemia Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1989 May 1

PMID 2539498

Citations 17

Authors

P L Green

D A Kaehler

L M Bennett

R Risser

Affiliations

Soon will be listed here.

Abstract

Helper virus-free Abelson murine leukemia virus (A-MuLV) was used to induce monoclonal pre-B-cell tumors in mice. The clonality, patterns of immunoglobulin heavy-chain gene rearrangement, tumorigenicity, and v-abl oncogene expression in individual preleukemic and leukemic colonies were compared. Our results indicate that A-MuLV preleukemic cells with low or undetectable tumorigenic potential give rise to leukemic cells with high tumorigenic potential by a process of subclone selection. The levels of v-abl oncogene product in preleukemic and leukemic cell populations were not significantly different. These results suggest that an additional event(s) unrelated to the level of the v-abl protein product is required for A-MuLV-transformed cells to become fully malignant.

Citing Articles

Role of ABL family kinases in cancer: from leukaemia to solid tumours.

Greuber E, Smith-Pearson P, Wang J, Pendergast A Nat Rev Cancer. 2013; 13(8):559-71.

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Abelson virus transformation prevents TRAIL expression by inhibiting FoxO3a and NF-kappaB.

Wilson M, McWhirter S, Amin R, Huang D, Schlissel M Mol Cells. 2010; 29(4):333-41.

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NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.

Nakamura Y, Grumont R, Gerondakis S Mol Cell Biol. 2002; 22(15):5563-74.

PMID: 12101248 PMC: 133951. DOI: 10.1128/MCB.22.15.5563-5574.2002.

The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation.

Reitmair A, Mak T, Rosenberg N Mol Cell Biol. 2000; 20(22):8373-81.

PMID: 11046134 PMC: 102144. DOI: 10.1128/MCB.20.22.8373-8381.2000.

Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells.

Mostecki J, Halgren A, Radfar A, Sachs Z, Ravitz J, Thome K J Virol. 2000; 74(20):9479-87.

PMID: 11000217 PMC: 112377. DOI: 10.1128/jvi.74.20.9479-9487.2000.

References

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

Poirier Y, Kozak C, Jolicoeur P . Identification of a common helper provirus integration site in Abelson murine leukemia virus-induced lymphoma DNA. J Virol. 1988; 62(11):3985-92. PMC: 253826. DOI: 10.1128/JVI.62.11.3985-3992.1988. View

Scher C, Siegler R . Direct transformation of 3T3 cells by Abelson murine leukaemia virus. Nature. 1975; 253(5494):729-31. DOI: 10.1038/253729a0. View

Sklar M, Shevach E, Green I, Potter M . Transplantation and preliminary characterisation of lymphocyte surface markers of Abelson virus-induced lymphomas. Nature. 1975; 253(5492):550-2. DOI: 10.1038/253550a0. View

Southern E . Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975; 98(3):503-17. DOI: 10.1016/s0022-2836(75)80083-0. View

Rosenberg N, Baltimore D . A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med. 1976; 143(6):1453-63. PMC: 2190217. DOI: 10.1084/jem.143.6.1453. View

Siden E, Baltimore D, Clark D, Rosenberg N . Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell. 1979; 16(2):389-96. DOI: 10.1016/0092-8674(79)90014-x. View

Witte O, Dasgupta A, Baltimore D . Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature. 1980; 283(5750):826-31. DOI: 10.1038/283826a0. View

Newell N, Richards J, Tucker P, Blattner F . J genes for heavy chain immunoglobulins of mouse. Science. 1980; 209(4461):1128-32. DOI: 10.1126/science.6250219. View

10.

Rosenberg N, Clark D, Witte O . Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation. J Virol. 1980; 36(3):766-74. PMC: 353704. DOI: 10.1128/JVI.36.3.766-774.1980. View

11.

Sefton B, Hunter T, Raschke W . Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. Proc Natl Acad Sci U S A. 1981; 78(3):1552-6. PMC: 319169. DOI: 10.1073/pnas.78.3.1552. View

12.

Whitlock C, Witte O . Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential. J Virol. 1981; 40(2):577-84. PMC: 256661. DOI: 10.1128/JVI.40.2.577-584.1981. View

13.

Waneck G, Rosenberg N . Abelson leukemia virus induces lymphoid and erythroid colonies in infected fetal cell cultures. Cell. 1981; 26(1 Pt 1):79-89. DOI: 10.1016/0092-8674(81)90035-0. View

14.

Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D . Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell. 1981; 27(2 Pt 1):381-90. DOI: 10.1016/0092-8674(81)90421-9. View

15.

Horowitz J, Risser R . A locus that enhances the induction of endogenous ecotropic murine leukemia viruses is distinct from genome-length ecotropic proviruses. J Virol. 1982; 44(3):950-7. PMC: 256354. DOI: 10.1128/JVI.44.3.950-957.1982. View

16.

Whitlock C, Ziegler S, Witte O . Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes. Mol Cell Biol. 1983; 3(4):596-604. PMC: 368575. DOI: 10.1128/mcb.3.4.596-604.1983. View

17.

Land H, Parada L, Weinberg R . Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature. 1983; 304(5927):596-602. DOI: 10.1038/304596a0. View

18.

Ruley H . Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature. 1983; 304(5927):602-6. DOI: 10.1038/304602a0. View

19.

Whitlock C, Robertson D, Witte O . Murine B cell lymphopoiesis in long term culture. J Immunol Methods. 1984; 67(2):353-69. DOI: 10.1016/0022-1759(84)90475-7. View

20.

Ohno S, Migita S, Wiener F, BABONITS M, Klein G, MUSHINSKI J . Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus. J Exp Med. 1984; 159(6):1762-77. PMC: 2187320. DOI: 10.1084/jem.159.6.1762. View