AHTPDB: a Comprehensive Platform for Analysis and Presentation of Antihypertensive Peptides

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2014 Nov 14

PMID 25392419

Citations 61

Authors

Ravi Kumar

Kumardeep Chaudhary

Minakshi Sharma

Gandharva Nagpal

Jagat Singh Chauhan

Sandeep Singh

Ankur Gautam

Gajendra P S Raghava

Affiliations

Soon will be listed here.

Abstract

AHTPDB (http://crdd.osdd.net/raghava/ahtpdb/) is a manually curated database of experimentally validated antihypertensive peptides. Information pertaining to peptides with antihypertensive activity was collected from research articles and from various peptide repositories. These peptides were derived from 35 major sources that include milk, egg, fish, pork, chicken, soybean, etc. In AHTPDB, most of the peptides belong to a family of angiotensin-I converting enzyme inhibiting peptides. The current release of AHTPDB contains 5978 peptide entries among which 1694 are unique peptides. Each entry provides detailed information about a peptide like sequence, inhibitory concentration (IC50), toxicity/bitterness value, source, length, molecular mass and information related to purification of peptides. In addition, the database provides structural information of these peptides that includes predicted tertiary and secondary structures. A user-friendly web interface with various tools has been developed to retrieve and analyse the data. It is anticipated that AHTPDB will be a useful and unique resource for the researchers working in the field of antihypertensive peptides.

Citing Articles

A Sweet Almond Globulin Multifunctional Peptide: Identification, In Silico Screening, Restraint Mechanisms to Keap1 and ACE, and Antihypertensive and Ferrous Transport Efficiency.

Xu B, Long P, Zheng Y, Feng C, Zhuang Y, Wu X Nutrients. 2025; 17(5).

PMID: 40077777 PMC: 11901700. DOI: 10.3390/nu17050907.

StackAHTPs: An explainable antihypertensive peptides identifier based on heterogeneous features and stacked learning approach.

Ghulam A, Arif M, Unar A, A Thafar M, Albaradei S, Worachartcheewan A IET Syst Biol. 2025; 19(1):e70002.

PMID: 39905861 PMC: 11794993. DOI: 10.1049/syb2.70002.

Goat Milk Protein-Derived ACE Inhibitory Peptide SLPQ Exerts Hypertension Alleviation Effects Partially by Regulating the Inflammatory Stress of Endothelial Cells.

Xing S, Zhang X, Mu T, Cao J, Zhao K, Han B Foods. 2024; 13(21).

PMID: 39517176 PMC: 11545510. DOI: 10.3390/foods13213392.

Introducing enzymatic cleavage features and transfer learning realizes accurate peptide half-life prediction across species and organs.

Tan X, Liu Q, Fang Y, Yang S, Chen F, Wang J Brief Bioinform. 2024; 25(4).

PMID: 39038937 PMC: 11262833. DOI: 10.1093/bib/bbae350.

Alcalase-Based Chickpea ( L.) Protein Hydrolysates Efficiently Reduce Systolic Blood Pressure in Spontaneously Hypertensive Rats.

Figueroa-Salcido O, Aramburo-Galvez J, Mora-Melgem J, Camacho-Cervantes D, Gracia-Valenzuela M, Cuevas-Rodriguez E Foods. 2024; 13(8).

PMID: 38672889 PMC: 11049421. DOI: 10.3390/foods13081216.

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