Modern Reproductive Patterns Associated with Estrogen Receptor Positive but Not Negative Breast Cancer Susceptibility

Overview

Journal Evol Med Public Health

Publisher Oxford University Press

Specialty General Medicine

Date 2014 Nov 13

PMID 25389105

Citations 19

Authors

C Athena Aktipis

Bruce J Ellis

Katherine K Nishimura

Robert A Hiatt

Affiliations

Soon will be listed here.

Abstract

It has long been accepted that modern reproductive patterns are likely contributors to breast cancer susceptibility because of their influence on hormones such as estrogen and the importance of these hormones in breast cancer. We conducted a meta-analysis to assess whether this 'evolutionary mismatch hypothesis' can explain susceptibility to both estrogen receptor positive (ER-positive) and estrogen receptor negative (ER-negative) cancer. Our meta-analysis includes a total of 33 studies and examines parity, age of first birth and age of menarche broken down by estrogen receptor status. We found that modern reproductive patterns are more closely linked to ER-positive than ER-negative breast cancer. Thus, the evolutionary mismatch hypothesis for breast cancer can account for ER-positive breast cancer susceptibility but not ER-negative breast cancer.

Citing Articles

Risk factors for breast cancer subtypes by race and ethnicity: A scoping review of the literature.

Hurson A, Ahearn T, Koka H, Jenkins B, Harris A, Roberts S medRxiv. 2024; .

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Risk factors for breast cancer subtypes by race and ethnicity: a scoping review.

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Cancer hygiene hypothesis: A test from wild captive mammals.

Dujon A, Jeanjean J, Vincze O, Giraudeau M, Lemaitre J, Pujol P Ecol Evol. 2023; 13(9):e10547.

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Reproductive history and breast cancer survival: Findings from the African breast cancer-Disparities in outcomes cohort and implications of Africa's fertility transition on breast cancer prognosis.

Boucheron P, Anele A, Offiah A, Zietsman A, Galukande M, Parham G Int J Cancer. 2022; 152(9):1804-1816.

PMID: 36545890 PMC: 10070810. DOI: 10.1002/ijc.34411.

Early life adversity, reproductive history and breast cancer risk.

Boddy A, Rupp S, Yu Z, Hanson H, Aktipis A, Smith K Evol Med Public Health. 2022; 10(1):429-438.

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