Distinct Factors Bind the AP-1 Consensus Sites in Gibbon Ape Leukemia Virus and Simian Virus 40 Enhancers

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1989 Apr 1

PMID 2538654

Citations 13

Authors

J P Quinn

M Takimoto

M Iadarola

N Holbrook

D Levens

Affiliations

Soon will be listed here.

Abstract

We have demonstrated that the gibbon ape leukemia virus (GALV) enhancer AP-1 element and the simian virus 40 AP-1 enhancer element bind different factors in HeLa nuclear extracts. A 39-kilodalton HeLa nuclear protein and the c-fos protein bind to the GALV element. Antibodies to c-fos abolish binding to the GALV AP-1 site. In contrast, anti-c-fos immunoglobulin fails to inhibit formation of the simian virus 40-specific complex from extracts of HeLa cells. Thus, AP-1-binding complexes are subject to compositional variation at different binding sites.

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