Response of the Human T-cell Leukemia Virus Type 1 Long Terminal Repeat to Cyclic AMP

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1989 Apr 1

PMID 2538645

Citations 34

Authors

H T Poteat

P Kadison

K McGuire

L Park

R E Park

J G Sodroski

W A Haseltine

Affiliations

Soon will be listed here.

Abstract

The sequences that control transcriptional initiation of the provirus of the human T-cell leukemia virus type 1 (HTLV-1) are shown to be responsive to intracellular levels of cyclic AMP. A heptanucleotide sequence present within the 21-nucleotide repeat sequence that is similar to the cyclic AMP-responsive consensus (CRE) sequence was required for cyclic AMP-mediated increase in gene expression. Although the CRE-like sequences were contained within sequences that were responsive to the virally encoded trans-activator (tax), the evidence presented indicates that the mechanisms of promoter induction by the tax product and cyclic AMP are independent. The implication of cyclic AMP stimulation of HTLV-1 provirus gene expression for long-term persistence of infected T cells and for virus-induced transformation is discussed.

Citing Articles

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Heym S, Krebs P, Ott K, Donhauser N, Kemeter L, Simon F Pathogens. 2024; 13(11).

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Regulation of Expression and Latency in BLV and HTLV.

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Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1.

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Upregulation of human T-cell leukemia virus type 1 antisense transcription by the viral tax protein.

Landry S, Halin M, Vargas A, Lemasson I, Mesnard J, Barbeau B J Virol. 2008; 83(4):2048-54.

PMID: 19073733 PMC: 2643783. DOI: 10.1128/JVI.01264-08.

T-cell receptor/CD28 engagement when combined with prostaglandin E2 treatment leads to potent activation of human T-cell leukemia virus type 1.

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PMID: 14512564 PMC: 224985. DOI: 10.1128/jvi.77.20.11170-11179.2003.

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