Designer Self-assembling Hydrogel Scaffolds Can Impact Skin Cell Proliferation and Migration

Overview

Journal Sci Rep

Specialty Science

Date 2014 Nov 12

PMID 25384420

Citations 23

Authors

Michael Bradshaw

Diwei Ho

Mark W Fear

Fabrizio Gelain

Fiona M Wood

K Swaminathan Iyer

Affiliations

Soon will be listed here.

Abstract

There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized nanofibers from the self-assembling peptide, RADA16. We demonstrate that adding different functional motifs to the RADA16 base peptide can influence the rate of proliferation and migration of keratinocytes and dermal fibroblasts. Relative to unmodified RADA16; the Collagen I motif significantly promotes cell migration, and reduces proliferation.

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