Class Switch Recombination and Somatic Hypermutation of Virus-neutralizing Antibodies Are Not Essential for Control of Friend Retrovirus Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2014 Nov 8

PMID 25378499

Citations 9

Authors

Maiko Kato

Sachiyo Tsuji-Kawahara

Yuri Kawasaki

Saori Kinoshita

Tomomi Chikaishi

Shiki Takamura

Makoto Fujisawa

Akira Kawada

Masaaki Miyazawa

Affiliations

Soon will be listed here.

Abstract

Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4+ T cells.

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