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Variable Electrobehavioral Patterns During Focal Nonconvulsive Status Epilepticus Induced by Unilateral Intrahippocampal Injection of Kainic Acid

Overview
Journal Epilepsia
Specialty Neurology
Date 2014 Nov 8
PMID 25378199
Citations 2
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Abstract

Objective: Nonconvulsive status epilepticus (ncSE) is a severe condition that may result in neurologic sequelae and epilepsy resistant to pharmacologic treatment. We analyze here seizure and electroencephalography (EEG) patterns and their correlation to the development of a chronic epileptic condition in a guinea pig model of focal ncSE induced by intrahippocampal injection of kainic acid (KA).

Methods: Electrobehavioral patterns during ncSE induced by unilateral injection of 1 μg of KA in the CA1 region of the hippocampus were characterized by continuous video-EEG monitoring in 13 guinea pigs bilaterally implanted with recording electrodes in the hippocampus and neocortex.

Results: Video-EEG analysis demonstrates a high variability of seizure type and duration during KA-induced ncSE. Seizures showed focal signs correlated with diverse epileptiform EEG discharge distributions, either diffuse or localized. Nonfocal (bilateral motor) signs during seizures most likely correlated with a diffuse EEG pattern. The evolution into a chronic epileptic condition correlated neither with the severity of seizure pattern nor with the diffusion of the EEG discharges observed during the ncSE.

Significance: Video-EEG monitoring in a guinea pig model of ncSE induced by unilateral hippocampal injection of KA demonstrates a high variability of electrobehavioral patterns. We demonstrate that the seizure severity score during focal ncSE is not a predictor of the evolution into a chronic epileptic condition of mesial temporal lobe epilepsy.

Citing Articles

Status Epilepticus.

Seinfeld S, Goodkin H, Shinnar S Cold Spring Harb Perspect Med. 2016; 6(3):a022830.

PMID: 26931807 PMC: 4772080. DOI: 10.1101/cshperspect.a022830.


Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry.

Puttachary S, Sharma S, Tse K, Beamer E, Sexton A, Crutison J PLoS One. 2015; 10(7):e0131705.

PMID: 26161754 PMC: 4498886. DOI: 10.1371/journal.pone.0131705.