Vitamin D and Skin Cancer

Overview

Journal Photochem Photobiol

Specialties Biochemistry
Biology
Chemistry

Date 2014 Nov 8

PMID 25378147

Citations 12

Authors

Erin M Burns

Craig A Elmets

Nabiha Yusuf

Affiliations

Soon will be listed here.

Abstract

Vitamin D signaling plays a key role in many important processes, including cellular proliferation, differentiation and apoptosis, immune regulation, hormone secretion and skeletal health. Furthermore, vitamin D production and supplementation have been shown to exert protective effects via an unknown signaling mechanism involving the vitamin D receptor (VDR) in several diseases and cancer types, including skin cancer. With over 3.5 million new diagnoses in 2 million patients annually, skin cancer is the most common cancer type in the United States. While ultraviolet B (UVB) radiation is the main etiologic factor for nonmelanoma skin cancer (NMSC), UVB also induces cutaneous vitamin D production. This paradox has been the subject of contradictory findings in the literature in regards to amount of sun exposure necessary for appropriate vitamin D production, as well as any beneficial or detrimental effects of vitamin D supplementation for disease prevention. Further clinical and epidemiological studies are necessary to elucidate the role of vitamin D in skin carcinogenesis.

Citing Articles

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Characterization of the CpG Island Hypermethylated Phenotype Subclass in Primary Melanomas.

Conway K, Tsai Y, Edmiston S, Parker J, Parrish E, Hao H J Invest Dermatol. 2021; 142(7):1869-1881.e10.

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Vitamin D and Other Differentiation-promoting Agents as Neoadjuvants for Photodynamic Therapy of Cancer.

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Sun exposure, skin lesions and vitamin D production: evaluation in a population of fishermen.

Coutinho R, Santos A, Gomes da Costa J, Vanderlei A An Bras Dermatol. 2019; 94(3):279-286.

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Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus).

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