Protein Kinases Are Potential Targets to Treat Inflammatory Bowel Disease

Overview

Journal World J Gastrointest Pharmacol Ther

Publisher Baishideng Publishing Group

Date 2014 Nov 7

PMID 25374761

Citations 7

Authors

Lei Yang

Yutao Yan

Affiliations

Soon will be listed here.

Abstract

Protein kinases play a crucial role in the pathogenesis of inflammatory bowel disease (IBD), the two main forms of which are ulcerative colitis and Crohn's disease. In this article, we will review the mechanisms of involvement of protein kinases in the pathogenesis of and intervention against IBD, in terms of their effects on genetics, microbiota, mucous layer and tight junction, and the potential of protein kinases as therapeutic targets against IBD.

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