MicroRNAs in Nasopharyngeal Carcinoma

Overview

Journal Chin J Cancer

Publisher Biomed Central

Specialty Oncology

Date 2014 Nov 5

PMID 25367334

Citations 22

Authors

Jeff P Bruce

Fei-Fei Liu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) provide insight into both the biology and clinical behavior of many human cancers, including nasopharyngeal carcinoma (NPC). The dysregulation of miRNAs in NPC results in a variety of tumor-promoting effects. Furthermore, several miRNAs are prognostic markers for NPC. In addition to cellular miRNAs, NPC samples also often contain miRNAs encoded by Epstein-Barr virus, and these miRNAs may impact NPC biology by targeting both cellular and viral genes. Given their numerous putative roles in NPC development and progression, a thorough understanding of the impact of miRNA dysregulation in NPC is expected to shed light on useful biomarkers and therapeutic targets for the clinical management of this disease. In this review, we describe the efforts to date to identify and characterize such miRNAs in the context of NPC.

Citing Articles

Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis.

Zhou S, Cao C, Hu J Biochem Genet. 2023; 61(5):1967-1986.

PMID: 36899270 DOI: 10.1007/s10528-023-10351-7.

Nomogram for distant metastasis-free survival in patients with locoregionally advanced nasopharyngeal carcinoma.

Yang H, Zhang R, Zhang R, Zhang B, Xie Y, Qin G Strahlenther Onkol. 2022; 198(9):828-837.

PMID: 35384452 DOI: 10.1007/s00066-022-01926-1.

MicroRNA-384 inhibits nasopharyngeal carcinoma growth and metastasis via binding to Smad5 and suppressing the Wnt/β-catenin axis.

Zeng X, Liao H, Wang F Cytotechnology. 2021; 73(2):203-215.

PMID: 33911345 PMC: 8035371. DOI: 10.1007/s10616-021-00458-3.

Integrative analysis of miRNAs-mRNAs reveals that miR-182 up-regulation contributes to proliferation and invasion of nasopharyngeal carcinoma by targeting PTEN.

Shi Z, Wang R, Huang L, Chen X, Xu M, Zha D Aging (Albany NY). 2020; 12(12):11568-11578.

PMID: 32541092 PMC: 7343470. DOI: 10.18632/aging.103316.

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma.

Tian Y, Tang L, Yi P, Pan Q, Han Y, Shi Y J Cancer. 2020; 11(13):3976-3985.

PMID: 32328201 PMC: 7171507. DOI: 10.7150/jca.42734.

References

Lo A, To K, Lo K, Lung R, Hui J, Liao G . Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci U S A. 2007; 104(41):16164-9. PMC: 2042179. DOI: 10.1073/pnas.0702896104. View

Yang X, Ni W, Lei K . miR-200b suppresses cell growth, migration and invasion by targeting Notch1 in nasopharyngeal carcinoma. Cell Physiol Biochem. 2013; 32(5):1288-98. DOI: 10.1159/000354527. View

Lung R, Tong J, Sung Y, Leung P, Ng D, Chau S . Modulation of LMP2A expression by a newly identified Epstein-Barr virus-encoded microRNA miR-BART22. Neoplasia. 2009; 11(11):1174-84. PMC: 2767219. DOI: 10.1593/neo.09888. View

Wang D, Wang S, Liu Q, Wang M, Wang C, Yang H . SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway. Oncol Rep. 2013; 29(6):2341-7. DOI: 10.3892/or.2013.2376. View

Nair V, Maeda L, Ioannidis J . Clinical outcome prediction by microRNAs in human cancer: a systematic review. J Natl Cancer Inst. 2012; 104(7):528-40. PMC: 3317879. DOI: 10.1093/jnci/djs027. View

Schwarz D, Hutvagner G, Du T, Xu Z, Aronin N, Zamore P . Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003; 115(2):199-208. DOI: 10.1016/s0092-8674(03)00759-1. View

Kozomara A, Griffiths-Jones S . miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 2010; 39(Database issue):D152-7. PMC: 3013655. DOI: 10.1093/nar/gkq1027. View

Dolken L, Malterer G, Erhard F, Kothe S, Friedel C, Suffert G . Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe. 2010; 7(4):324-334. DOI: 10.1016/j.chom.2010.03.008. View

Marquitz A, Mathur A, Nam C, Raab-Traub N . The Epstein-Barr Virus BART microRNAs target the pro-apoptotic protein Bim. Virology. 2011; 412(2):392-400. PMC: 3340891. DOI: 10.1016/j.virol.2011.01.028. View

10.

Borchert G, Lanier W, Davidson B . RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 2006; 13(12):1097-101. DOI: 10.1038/nsmb1167. View

11.

Krek A, Grun D, Poy M, Wolf R, Rosenberg L, Epstein E . Combinatorial microRNA target predictions. Nat Genet. 2005; 37(5):495-500. DOI: 10.1038/ng1536. View

12.

Orom U, Nielsen F, Lund A . MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell. 2008; 30(4):460-71. DOI: 10.1016/j.molcel.2008.05.001. View

13.

Zhang L, Deng T, Li X, Liu H, Zhou H, Ma J . microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis. 2010; 31(4):559-66. DOI: 10.1093/carcin/bgp335. View

14.

Hui A, Bruce J, Alajez N, Shi W, Yue S, Perez-Ordonez B . Significance of dysregulated metadherin and microRNA-375 in head and neck cancer. Clin Cancer Res. 2011; 17(24):7539-50. DOI: 10.1158/1078-0432.CCR-11-2102. View

15.

Yu S, Chen H, Chang G, Chen C, Chen H, Singh S . MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell. 2008; 13(1):48-57. DOI: 10.1016/j.ccr.2007.12.008. View

16.

Iorio M, Ferracin M, Liu C, Veronese A, Spizzo R, Sabbioni S . MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005; 65(16):7065-70. DOI: 10.1158/0008-5472.CAN-05-1783. View

17.

Lu J, Xu X, Liu X, Peng Y, Zhang B, Wang L . Predictive value of miR-9 as a potential biomarker for nasopharyngeal carcinoma metastasis. Br J Cancer. 2013; 110(2):392-8. PMC: 3899774. DOI: 10.1038/bjc.2013.751. View

18.

Kim V, Han J, Siomi M . Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009; 10(2):126-39. DOI: 10.1038/nrm2632. View

19.

John B, Enright A, Aravin A, Tuschl T, Sander C, Marks D . Human MicroRNA targets. PLoS Biol. 2004; 2(11):e363. PMC: 521178. DOI: 10.1371/journal.pbio.0020363. View

20.

Yu L, Lu J, Zhang B, Liu X, Wang L, Li S . miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2. Oncol Lett. 2013; 5(4):1223-1228. PMC: 3629195. DOI: 10.3892/ol.2013.1173. View