DNA Repair Mechanisms and Human Cytomegalovirus (HCMV) Infection

Overview

Journal Folia Microbiol (Praha)

Publisher Springer

Specialty Microbiology

Date 2014 Nov 5

PMID 25366712

Citations 5

Authors

Beata Smolarz

Jan Wilczynski

Dorota Nowakowska

Affiliations

Soon will be listed here.

Abstract

Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleotide excision, homologous recombination and nonhomologous end joining. Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection.

Citing Articles

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