Dietary Vitamin A Regulates Wingless-related MMTV Integration Site Signaling to Alter the Hair Cycle

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2014 Nov 2

PMID 25361771

Citations 11

Authors

Liye Suo

John P Sundberg

Helen B Everts

Affiliations

Soon will be listed here.

Abstract

Alopecia areata (AA) is an autoimmune hair loss disease caused by a cell-mediated immune attack of the lower portion of the cycling hair follicle. Feeding mice 3-7 times the recommended level of dietary vitamin A accelerated the progression of AA in the graft-induced C3H/HeJ mouse model of AA. In this study, we also found that dietary vitamin A, in a dose dependent manner, activated the hair follicle stem cells (SCs) to induce the development and growth phase of the hair cycle (anagen), which may have made the hair follicle more susceptible to autoimmune attack. Our purpose here is to determine the mechanism by which dietary vitamin A regulates the hair cycle. We found that vitamin A in a dose-dependent manner increased nuclear localized beta-catenin (CTNNB1; a marker of canonical wingless-type Mouse Mammary Tumor Virus integration site family (WNT) signaling) and levels of WNT7A within the hair follicle bulge in these C3H/HeJ mice. These findings suggest that feeding mice high levels of dietary vitamin A increases WNT signaling to activate hair follicle SCs.

Citing Articles

Retinoic acid drives hair follicle stem cell activation via Wnt/β-catenin signalling in androgenetic alopecia.

Wen L, Fan Z, Huang W, Miao Y, Zhang J, Liu B J Eur Acad Dermatol Venereol. 2024; 39(1):189-201.

PMID: 38629345 PMC: 11664453. DOI: 10.1111/jdv.20000.

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss.

Natarelli N, Gahoonia N, Sivamani R J Clin Med. 2023; 12(3).

PMID: 36769541 PMC: 9917549. DOI: 10.3390/jcm12030893.

An overview of the genetic aspects of hair loss and its connection with nutrition.

Gokce N, Basgoz N, Kenanoglu S, Akalin H, Ozkul Y, Ergoren M J Prev Med Hyg. 2022; 63(2 Suppl 3):E228-E238.

PMID: 36479473 PMC: 9710406. DOI: 10.15167/2421-4248/jpmh2022.63.2S3.2765.

Vitamin A in Skin and Hair: An Update.

VanBuren C, Everts H Nutrients. 2022; 14(14).

PMID: 35889909 PMC: 9324272. DOI: 10.3390/nu14142952.

Dietary Habits in Japanese Patients with Alopecia Areata.

Hagino T, Okazaki S, Serizawa N, Suzuki K, Kaga M, Otsuka Y Clin Cosmet Investig Dermatol. 2021; 14:1579-1591.

PMID: 34737597 PMC: 8560057. DOI: 10.2147/CCID.S335440.

References

Xu Q, Kopp J . Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair. Semin Nephrol. 2012; 32(3):287-94. PMC: 3407374. DOI: 10.1016/j.semnephrol.2012.04.008. View

Park S, Murphy S, Martin C, Kolonel L . Nutrient intake from multivitamin/mineral supplements is similar among users from five ethnic groups: the Multiethnic Cohort Study. J Am Diet Assoc. 2008; 108(3):529-33. DOI: 10.1016/j.jada.2007.12.011. View

WOLBACH S, Howe P . TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN. J Exp Med. 2009; 42(6):753-77. PMC: 2131078. DOI: 10.1084/jem.42.6.753. View

Girard C, Dereure O, Blatiere V, Guillot B, Bessis D . Vitamin a deficiency phrynoderma associated with chronic giardiasis. Pediatr Dermatol. 2006; 23(4):346-9. DOI: 10.1111/j.1525-1470.2006.00261.x. View

Everts H, King Jr L, Sundberg J, Ong D . Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation. J Invest Dermatol. 2004; 123(2):258-63. DOI: 10.1111/j.0022-202X.2004.23223.x. View

Everts H, Sundberg J, King Jr L, Ong D . Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle. J Invest Dermatol. 2007; 127(7):1593-604. DOI: 10.1038/sj.jid.5700753. View

Berth-Jones J, Hutchinson P . Novel cycle changes in scalp hair are caused by etretinate therapy. Br J Dermatol. 1995; 132(3):367-75. DOI: 10.1111/j.1365-2133.1995.tb08669.x. View

Reddy S, Andl T, Bagasra A, Lu M, Epstein D, Morrisey E . Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev. 2001; 107(1-2):69-82. DOI: 10.1016/s0925-4773(01)00452-x. View

Gilhar A, Paus R, Kalish R . Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest. 2007; 117(8):2019-27. PMC: 1934574. DOI: 10.1172/JCI31942. View

10.

Kandyba E, Leung Y, Chen Y, Widelitz R, Chuong C, Kobielak K . Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A. 2013; 110(4):1351-6. PMC: 3557042. DOI: 10.1073/pnas.1121312110. View

11.

Al Tanoury Z, Piskunov A, Rochette-Egly C . Vitamin A and retinoid signaling: genomic and nongenomic effects. J Lipid Res. 2013; 54(7):1761-75. PMC: 3679380. DOI: 10.1194/jlr.R030833. View

12.

Baldwin T, Rood K, Kelly E, Hall J . Dermatopathy in juvenile Angus cattle due to vitamin A deficiency. J Vet Diagn Invest. 2012; 24(4):763-6. DOI: 10.1177/1040638712445767. View

13.

WOLBACH S, Howe P . EPITHELIAL REPAIR IN RECOVERY FROM VITAMIN A DEFICIENCY : AN EXPERIMENTAL STUDY. J Exp Med. 2009; 57(3):511-26. PMC: 2132241. DOI: 10.1084/jem.57.3.511. View

14.

Shamonki M, Kligman I, Shamonki J, Schattman G, Hyjek E, Spandorfer S . Immunohistochemical expression of endometrial L-selectin ligand is higher in donor egg recipients with embryonic implantation. Fertil Steril. 2006; 86(5):1365-75. DOI: 10.1016/j.fertnstert.2006.04.035. View

15.

Niehrs C . The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol. 2012; 13(12):767-79. DOI: 10.1038/nrm3470. View

16.

Liu Y, Liu Y, Zhang R, Wang X, Huang F, Yan Z . All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways. Int J Biochem Cell Biol. 2013; 47:47-56. DOI: 10.1016/j.biocel.2013.11.018. View

17.

Ocon J, Cabrejas C, Altemir J, Moros M . Phrynoderma: a rare dermatologic complication of bariatric surgery. JPEN J Parenter Enteral Nutr. 2012; 36(3):361-4. DOI: 10.1177/0148607111422067. View

18.

Everts H . Endogenous retinoids in the hair follicle and sebaceous gland. Biochim Biophys Acta. 2011; 1821(1):222-9. PMC: 3237781. DOI: 10.1016/j.bbalip.2011.08.017. View

19.

Duester G . Retinoid signaling in control of progenitor cell differentiation during mouse development. Semin Cell Dev Biol. 2013; 24(10-12):694-700. PMC: 3849222. DOI: 10.1016/j.semcdb.2013.08.001. View

20.

Muller-Rover S, Handjiski B, van der Veen C, Eichmuller S, Foitzik K, McKay I . A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001; 117(1):3-15. DOI: 10.1046/j.0022-202x.2001.01377.x. View