LIN28B Promotes Colon Cancer Migration and Recurrence

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Nov 1

PMID 25360631

Citations 27

Authors

Minghui Pang

Gang Wu

Xiaolin Hou

Nengyi Hou

Liqin Liang

Guiqing Jia

Ping Shuai

Bin Luo

Kang Wang

Guoxin Li

Affiliations

Soon will be listed here.

Abstract

LIN28B is involved in "stemness" and tumourigenesis by negatively regulating the maturation of let-7 microRNA family members. In this study, we showed that LIN28B expression promotes migration and recurrence of colon cancer. Immunohistochemistry and reverse-transcription polymerase chain reactions were performed to detect LIN28B expression in colon cancer tissue microarrays, paraffin-embedded surgical resected tissues and cancer cells. Loss-of-function, migration and proliferation analyses were performed to delineate the potential roles of LIN28B in colon cancer. LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence. LIN28B suppression inhibited the migration of SW480 colon cancer cells and facilitated the cytotoxicity induced by oxaliplatin in SW480 and HCT116 colon cancer cells. In conclusion, LIN28B overexpression contributes to colon tumourigenesis, and LIN28B may serve as a diagnostic tool and therapeutic target for colon cancer.

Citing Articles

The role of Lin28A and Lin28B in cancer beyond Let-7.

Cotino-Najera S, Garcia-Villa E, Cruz-Rosales S, Gariglio P, Diaz-Chavez J FEBS Lett. 2024; 598(24):2963-2979.

PMID: 39152528 PMC: 11665955. DOI: 10.1002/1873-3468.15004.

LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3.

Sugiura K, Masuike Y, Suzuki K, Shin A, Sakai N, Matsubara H JCI Insight. 2023; 8(14).

PMID: 37318881 PMC: 10443801. DOI: 10.1172/jci.insight.167310.

The role of LIN28B in tumor progression and metastasis in solid tumor entities.

Gewalt T, Noh K, Meder L Oncol Res. 2023; 31(2):101-115.

PMID: 37304235 PMC: 10208000. DOI: 10.32604/or.2023.028105.

Lin28 Regulates Cancer Cell Stemness for Tumour Progression.

Lin Z, Radaeva M, Cherkasov A, Dong X Cancers (Basel). 2022; 14(19).

PMID: 36230562 PMC: 9564245. DOI: 10.3390/cancers14194640.

Polymorphisms Confer a Higher Postoperative Recurrence Risk in Reproductive-Age Women with Endometrial Polyps.

Lu M, Li X, Niu J, Liu B Dis Markers. 2022; 2022:4824357.

PMID: 35273655 PMC: 8902632. DOI: 10.1155/2022/4824357.

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