The Modulatory Effect of Electrical Stimulation on the Excitability of the Corticospinal Tract Varies According to the Type of Muscle Contraction Being Performed

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2014 Nov 1

PMID 25360103

Citations 5

Authors

Kei Saito

Kenichi Sugawara

Shota Miyaguchi

Takuya Matsumoto

Hikari Kirimoto

Hiroyuki Tamaki

Hideaki Onishi

Affiliations

Soon will be listed here.

Abstract

Afferent input caused by electrical stimulation of a peripheral nerve increases corticospinal excitability during voluntary contractions, indicating that proprioceptive sensory input arriving at the cortex plays a fundamental role in modulating corticospinal excitability. The purpose of this study was to investigate whether the effect of electrical stimulation on the corticospinal excitability varies according to the type of muscle contraction being performed. Motor-evoked potentials (MEPs) were elicited by transcranial magnetic stimulation (TMS) during a shortening contraction, an isometric contraction, or no contraction of the first dorsal interosseous (FDI) muscle. In some trials, electrical stimulation of the ulnar nerve was performed at 110% of the sensory threshold or 110% of the motor threshold prior to TMS. Electrical stimulation involved either a train of 50 pulses at 10 Hz or a single pulse. Shortening contraction with the train of electrical stimuli significantly increased MEP amplitudes, and the increase was dependent on the type of stimulation. Isometric contraction with the train of electrical stimuli and electrical stimulation without voluntary contraction did not affect MEP amplitudes. A single pulse of electrical stimulation did not affect MEP amplitudes in any condition. Thus, electrical-stimulation-induced modulation of corticospinal excitability varied according to the type of muscle contraction performed and the type of stimulation. These results show that the type of contraction should be considered when using electrical stimulation for rehabilitation in patients with central nervous system lesions.

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References

Blakemore S, Wolpert D, Frith C . Central cancellation of self-produced tickle sensation. Nat Neurosci. 1999; 1(7):635-40. DOI: 10.1038/2870. View

Charlton C, Ridding M, Thompson P, Miles T . Prolonged peripheral nerve stimulation induces persistent changes in excitability of human motor cortex. J Neurol Sci. 2003; 208(1-2):79-85. DOI: 10.1016/s0022-510x(02)00443-4. View

Fujiwara T, Kasashima Y, Honaga K, Muraoka Y, Tsuji T, Osu R . Motor improvement and corticospinal modulation induced by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy in patients with chronic stroke. Neurorehabil Neural Repair. 2008; 23(2):125-32. DOI: 10.1177/1545968308321777. View

Tinazzi M, Zarattini S, Valeriani M, Romito S, Farina S, Moretto G . Long-lasting modulation of human motor cortex following prolonged transcutaneous electrical nerve stimulation (TENS) of forearm muscles: evidence of reciprocal inhibition and facilitation. Exp Brain Res. 2004; 161(4):457-64. DOI: 10.1007/s00221-004-2091-y. View

Chipchase L, Schabrun S, Hodges P . Corticospinal excitability is dependent on the parameters of peripheral electric stimulation: a preliminary study. Arch Phys Med Rehabil. 2011; 92(9):1423-30. DOI: 10.1016/j.apmr.2011.01.011. View

Hara Y, Obayashi S, Tsujiuchi K, Muraoka Y . The effects of electromyography-controlled functional electrical stimulation on upper extremity function and cortical perfusion in stroke patients. Clin Neurophysiol. 2013; 124(10):2008-15. DOI: 10.1016/j.clinph.2013.03.030. View

Chen R, Corwell B, Hallett M . Modulation of motor cortex excitability by median nerve and digit stimulation. Exp Brain Res. 1999; 129(1):77-86. DOI: 10.1007/s002210050938. View

Bolton D, Cauraugh J, Hausenblas H . Electromyogram-triggered neuromuscular stimulation and stroke motor recovery of arm/hand functions: a meta-analysis. J Neurol Sci. 2004; 223(2):121-7. DOI: 10.1016/j.jns.2004.05.005. View

Andrews R, Schabrun S, Ridding M, Galea M, Hodges P, Chipchase L . The effect of electrical stimulation on corticospinal excitability is dependent on application duration: a same subject pre-post test design. J Neuroeng Rehabil. 2013; 10:51. PMC: 3688368. DOI: 10.1186/1743-0003-10-51. View

10.

Chye L, Nosaka K, Murray L, Edwards D, Thickbroom G . Corticomotor excitability of wrist flexor and extensor muscles during active and passive movement. Hum Mov Sci. 2010; 29(4):494-501. DOI: 10.1016/j.humov.2010.03.003. View

11.

Seki K, Fetz E . Gating of sensory input at spinal and cortical levels during preparation and execution of voluntary movement. J Neurosci. 2012; 32(3):890-902. PMC: 3293372. DOI: 10.1523/JNEUROSCI.4958-11.2012. View

12.

Tarkka I, Pitkanen K, Popovic D, Vanninen R, Kononen M . Functional electrical therapy for hemiparesis alleviates disability and enhances neuroplasticity. Tohoku J Exp Med. 2011; 225(1):71-6. DOI: 10.1620/tjem.225.71. View

13.

Thompson A, Doran B, Stein R . Short-term effects of functional electrical stimulation on spinal excitatory and inhibitory reflexes in ankle extensor and flexor muscles. Exp Brain Res. 2005; 170(2):216-26. DOI: 10.1007/s00221-005-0203-y. View

14.

Khaslavskaia S, Ladouceur M, Sinkjaer T . Increase in tibialis anterior motor cortex excitability following repetitive electrical stimulation of the common peroneal nerve. Exp Brain Res. 2002; 145(3):309-15. DOI: 10.1007/s00221-002-1094-9. View

15.

Ridding M, McKay D, Thompson P, Miles T . Changes in corticomotor representations induced by prolonged peripheral nerve stimulation in humans. Clin Neurophysiol. 2001; 112(8):1461-9. DOI: 10.1016/s1388-2457(01)00592-2. View

16.

de Kroon J, IJzerman M, Chae J, Lankhorst G, Zilvold G . Relation between stimulation characteristics and clinical outcome in studies using electrical stimulation to improve motor control of the upper extremity in stroke. J Rehabil Med. 2005; 37(2):65-74. DOI: 10.1080/16501970410024190. View

17.

Khaslavskaia S, Sinkjaer T . Motor cortex excitability following repetitive electrical stimulation of the common peroneal nerve depends on the voluntary drive. Exp Brain Res. 2005; 162(4):497-502. DOI: 10.1007/s00221-004-2153-1. View

18.

Angel R, Malenka R . Velocity-dependent suppression of cutaneous sensitivity during movement. Exp Neurol. 1982; 77(2):266-74. DOI: 10.1016/0014-4886(82)90244-8. View

19.

Ridding M, Brouwer B, Miles T, Pitcher J, Thompson P . Changes in muscle responses to stimulation of the motor cortex induced by peripheral nerve stimulation in human subjects. Exp Brain Res. 2000; 131(1):135-43. DOI: 10.1007/s002219900269. View

20.

Sugawara K, Yamaguchi T, Tanabe S, Suzuki T, Saito K, Higashi T . Time-dependent changes in motor cortical excitability by electrical stimulation combined with voluntary drive. Neuroreport. 2013; 25(6):404-9. DOI: 10.1097/WNR.0000000000000108. View