» Articles » PMID: 25360078

Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells

Overview
Journal Immune Netw
Date 2014 Nov 1
PMID 25360078
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment of inflammatory and metabolic diseases. In this study, immunomodulatory effects of ZYM-201 on B cells were examined in vitro and in vivo. When splenocytes were activated with lipopolysaccharide (LPS), the major population which had shown an increase in cell numbers was B cells. However, when the B cells were treated with ZYM-201 after LPS activation, their cell numbers and the expression of major costimulatory molecules, CD80 and CD86, were decreased. Furthermore, the effect of LPS, which induces activation of NF-κB, was abolished by ZYM-201: LPS-stimulated B cells showed decrease of phosphorylation after treatment of ZYM-201. The same results were shown in vivo experiments. These results suggest that ZYM-201 may play a role in the modulation of inflammatory responses through inhibiting NF-κB activation and downregulating the expression of costimulatory molecules on B cells.

Citing Articles

Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model.

Lee E, Kim J, Kim T, Kim Y, Pak M, Jeon C Front Immunol. 2021; 12:737076.

PMID: 34659228 PMC: 8511399. DOI: 10.3389/fimmu.2021.737076.


Syk and IRAK1 Contribute to Immunopharmacological Activities of Anthraquinone-2-carboxlic Acid.

Park J, Son Y, Kim M, Cho J Molecules. 2016; 21(6).

PMID: 27338330 PMC: 6272897. DOI: 10.3390/molecules21060809.


Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid.

Park J, Kim S, Kim Y, Yang W, Kim Y, Hong S Mediators Inflamm. 2016; 2016:1903849.

PMID: 27057092 PMC: 4735930. DOI: 10.1155/2016/1903849.


Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice.

Son D, Hwang S, Kim M, Park U, Kim B Nutrients. 2015; 7(7):5469-83.

PMID: 26198246 PMC: 4517009. DOI: 10.3390/nu7075232.

References
1.
Goun E, Petrichenko V, Solodnikov S, Suhinina T, Kline M, Cunningham G . Anticancer and antithrombin activity of Russian plants. J Ethnopharmacol. 2002; 81(3):337-42. DOI: 10.1016/s0378-8741(02)00116-2. View

2.
Zhang G, Ghosh S . Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest. 2001; 107(1):13-9. PMC: 198554. DOI: 10.1172/JCI11837. View

3.
Tsukahara K, Moriwaki S, Fujimura T, Takema Y . Inhibitory effect of an extract of Sanguisorba officinalis L. on ultraviolet-B-induced photodamage of rat skin. Biol Pharm Bull. 2001; 24(9):998-1003. DOI: 10.1248/bpb.24.998. View

4.
East J . The effect of certain plant preparations on the fertility of laboratory mammals. 4. Sanguisorba officinalis L. J Endocrinol. 1955; 12(4):273-6. DOI: 10.1677/joe.0.0120273. View

5.
Choi J, Kim M, Cha B, Yoo E, Yoon K, Lee J . ZYM-201 sodium succinate ameliorates streptozotocin-induced hyperlipidemic conditions. Planta Med. 2011; 78(1):12-7. DOI: 10.1055/s-0031-1280219. View