Lessons from Rodent Models in Celiac Disease

Overview

Journal Mucosal Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2014 Oct 30

PMID 25354320

Citations 12

Authors

N Korneychuk

B Meresse

N Cerf-Bensussan

Affiliations

Soon will be listed here.

Abstract

Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of mouse models in order to explore pathogenic hypotheses, and also with the goal to design pretherapeutic models that could be used to test innovative therapies. Yet, modeling this complex multifactorial disease has been a very challenging task. Herein, we review how approaches in rodents have provided insight into celiac disease pathophysiology and also highlight the difficulties met to fully recapitulate the human disease.

Citing Articles

New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease.

Abadie V, Han A, Jabri B, Sollid L Gastroenterology. 2024; 167(1):4-22.

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Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity.

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Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease.

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Recent advances in celiac disease and refractory celiac disease.

Malamut G, Cording S, Cerf-Bensussan N F1000Res. 2019; 8.

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