Quality of Life in Patients with Osteoporotic Vertebral Fractures

Overview

Journal Asian Spine J

Date 2014 Oct 28

PMID 25346819

Citations 11

Authors

Sang-Pil Yoon

Seung-Hwan Lee

Chul-Hyun Ki

Young-Tae Lee

Sung-Ha Hong

Hwan-Mo Lee

Seong-Hwan Moon

Affiliations

Soon will be listed here.

Abstract

Study Design: A case-control study.

Purpose: To examine several dimensions of health-related quality of life (HRQL) in postmenopausal women with osteoporotic vertebral fractures, compared with a control group.

Overview Of Literature: Osteoporotic vertebral fractures are a major cause of morbidity among postmenopausal women. There have been many reports of a decrease in the quality of life in patients with osteoporotic vertebral fractures. However,few reports have analyzed which dimensions contribute to the decline in quality of life.

Methods: One thousand five hundred forty-five postmenopausal women aged 50 years and older from 17 study sites in nationwide hospitals were in enrolled in the study (between April 2008 and January 2009). HRQL was measured using the European Quality of Life 5 Domains (EQ-5D), and visual analogue scale (VAS).

Results: The average VAS of the case group was 57.80, and that of the control group was 64.10 (p=0.001). All domains of the EQ-5D score were significantly worse in the case group (p=0.001). Among the case group, the average VAS of the 559 patients (45%) who were operated on was 56.8, and that of the remaining 680 patients (55%) who were treated conservatively was 58.6 (p=0.135). Among the case group, the averages of each EQ-5D domain of the 559 patients (45%) who were operated on were: 1.87 in mobility, 1.81 in self-care, 1.99 in usual activities, 2.11 in pain, and 1.62 in anxiety or depression. Those of the 680 patients (55%) who were treated conservatively were: 1.72 in mobility, 1.60 in self-care, 1.76 in usual activities, 1.98 in pain, and 1.57 in anxiety or depression. Except for the domain of anxiety or depression, scores for the other domains were all significantly worse in the patients who were operated on (p=0.001).

Conclusions: Health related quality of life in the patients with osteoporotic vertebral fractures was significantly worse in both the EQ-5D domains and VAS. Among the osteoporotic vertebral fracture patients, the patients who were operated on had a worse quality of life in EQ-5D.

Citing Articles

Posterolateral Instrumented Fusion in Elderly Patients With a Single Osteoporotic Vertebral Fracture: Evaluation of Health-Related Quality of Life.

Kapetanakis S, Gkantsinikoudis N, Apostolakis S, Tsioulas P, Chaniotakis C Cureus. 2024; 16(2):e53498.

PMID: 38440031 PMC: 10910638. DOI: 10.7759/cureus.53498.

Vitamin D Supplementation and Its Impact on Different Types of Bone Fractures.

Erdmann J, Wicinski M, Szyperski P, Gajewska S, Ohla J, Slupski M Nutrients. 2023; 15(1).

PMID: 36615761 PMC: 9824692. DOI: 10.3390/nu15010103.

Validation of the European Quality of Life-5 Dimensions, 3-Level Version (EQ-5D-3L) in Patients With Osteoporotic Vertebral Fracture and Comparing Their Health-Related Quality of Life With That of the General Population in Korea.

Jeong J, Jo M, Chin D, Son W, Ock M, Lee J Korean J Neurotrauma. 2022; 18(1):64-74.

PMID: 35557648 PMC: 9064758. DOI: 10.13004/kjnt.2022.18.e19.

Assessment of Quality of Life and Pain Severity in Older Men with Osteoporosis: Cross-Sectional Study.

Nawrat-Szoltysik A, Miodonska Z, Piejko L, Szoltys B, Blaszczyszyn M, Matyja B Int J Environ Res Public Health. 2021; 18(21).

PMID: 34769791 PMC: 8583218. DOI: 10.3390/ijerph182111276.

Association between Osteoporotic Vertebral Compression Fractures and Age, Bone Mineral Density, and European Quality of Life-5 Dimensions in Korean Postmenopausal Women: A Nationwide Cross-sectional Observational Study.

Cho M, Moon S, Lee J, Lee J Clin Orthop Surg. 2021; 13(2):207-215.

PMID: 34094011 PMC: 8173246. DOI: 10.4055/cios20209.

References

Venmans A, Klazen C, Lohle P, Mali W, van Rooij W . Natural history of pain in patients with conservatively treated osteoporotic vertebral compression fractures: results from VERTOS II. AJNR Am J Neuroradiol. 2011; 33(3):519-21. PMC: 7966424. DOI: 10.3174/ajnr.A2817. View

Majumdar S, Kim N, Colman I, Chahal A, Raymond G, Jen H . Incidental vertebral fractures discovered with chest radiography in the emergency department: prevalence, recognition, and osteoporosis management in a cohort of elderly patients. Arch Intern Med. 2005; 165(8):905-9. DOI: 10.1001/archinte.165.8.905. View

Gold D . The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone. 1996; 18(3 Suppl):185S-189S. DOI: 10.1016/8756-3282(95)00500-5. View

Hall S, Criddle R, Comito T, Prince R . A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture. Osteoporos Int. 2000; 9(6):508-15. DOI: 10.1007/s001980050178. View

Brooks R . EuroQol: the current state of play. Health Policy. 1996; 37(1):53-72. DOI: 10.1016/0168-8510(96)00822-6. View

van Schoor N, Smit J, Twisk J, Lips P . Impact of vertebral deformities, osteoarthritis, and other chronic diseases on quality of life: a population-based study. Osteoporos Int. 2004; 16(7):749-56. DOI: 10.1007/s00198-004-1744-9. View

Delmas P, van de Langerijt L, Watts N, Eastell R, Genant H, Grauer A . Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study. J Bone Miner Res. 2005; 20(4):557-63. DOI: 10.1359/JBMR.041214. View

Miyakoshi N, Hongo M, Maekawa S, Ishikawa Y, Shimada Y, Itoi E . Back extensor strength and lumbar spinal mobility are predictors of quality of life in patients with postmenopausal osteoporosis. Osteoporos Int. 2007; 18(10):1397-403. DOI: 10.1007/s00198-007-0383-3. View

Adachi J, Adami S, Gehlbach S, Anderson Jr F, Boonen S, Chapurlat R . Impact of prevalent fractures on quality of life: baseline results from the global longitudinal study of osteoporosis in women. Mayo Clin Proc. 2010; 85(9):806-13. PMC: 2931616. DOI: 10.4065/mcp.2010.0082. View

10.

Lips P, van Schoor N . Quality of life in patients with osteoporosis. Osteoporos Int. 2004; 16(5):447-55. DOI: 10.1007/s00198-004-1762-7. View

11.

Klazen C, Verhaar H, Lohle P, Lampmann L, Juttmann J, Schoemaker M . Clinical course of pain in acute osteoporotic vertebral compression fractures. J Vasc Interv Radiol. 2010; 21(9):1405-9. DOI: 10.1016/j.jvir.2010.05.018. View

12.

Brazier J, Walters S, Nicholl J, Kohler B . Using the SF-36 and Euroqol on an elderly population. Qual Life Res. 1996; 5(2):195-204. DOI: 10.1007/BF00434741. View

13.

Naves Diaz M, Diaz Lopez J, Rodriguez Rebollar A, Gomez Alonso C, Diaz Corte C, Cannata Andia J . [Effect of vertebral fracture on health related quality of life in a Spanish population older than 54 years]. Med Clin (Barc). 2001; 116(14):533-5. DOI: 10.1016/s0025-7753(01)71895-7. View

14.

Tosteson A, Gabriel S, Grove M, Moncur M, Kneeland T, Melton 3rd L . Impact of hip and vertebral fractures on quality-adjusted life years. Osteoporos Int. 2002; 12(12):1042-9. DOI: 10.1007/s001980170015. View

15.

Sullivan P, Lawrence W, Ghushchyan V . A national catalog of preference-based scores for chronic conditions in the United States. Med Care. 2005; 43(7):736-49. DOI: 10.1097/01.mlr.0000172050.67085.4f. View

16.

Imagama S, Matsuyama Y, Hasegawa Y, Sakai Y, Ito Z, Ishiguro N . Back muscle strength and spinal mobility are predictors of quality of life in middle-aged and elderly males. Eur Spine J. 2010; 20(6):954-61. PMC: 3099149. DOI: 10.1007/s00586-010-1606-4. View