Biomarkers in Acute Kidney Injury: Are We Ready for Prime Time?

Overview

Journal Nephron Clin Pract

Publisher Karger

Specialty Nephrology

Date 2014 Oct 25

PMID 25343845

Citations 12

Authors

Prasad Devarajan

Patrick Murray

Affiliations

Soon will be listed here.

Abstract

Novel biomarkers are required to improve the timely detection of early acute kidney injury (AKI) and to improve the differential diagnosis, prognostic assessment, and management of AKI cases. It is anticipated that novel biomarkers of early structural AKI ('acute kidney damage') will provide critical diagnostic and prognostic stratification and complement functional markers such as serum creatinine. Further studies are required to conclusively demonstrate the association between early kidney damage biomarkers and clinical outcomes, both with and independently of functional markers, and to discern whether or not randomization to a treatment for AKI based on high structural/damage biomarker levels results in an improvement in kidney function and clinical outcomes.

Citing Articles

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Comparing machine learning and logistic regression for acute kidney injury prediction in trauma patients: A retrospective observational study at a single tertiary medical center.

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Biomarker-Guided Risk Assessment for Acute Kidney Injury: Time for Clinical Implementation?.

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Wallwitz J, Aigner P, Gadermaier E, Bauer E, Casanova E, Bauer A PLoS One. 2019; 14(8):e0220935.

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