» Articles » PMID: 25341517

Modulating MTOR in Aging and Health

Overview
Specialty Geriatrics
Date 2014 Oct 25
PMID 25341517
Citations 65
Authors
Affiliations
Soon will be listed here.
Abstract

The physiological responses to nutrient availability play a central role in aging and disease. Genetic and pharmacological studies have identified highly conserved cellular signaling pathways that influence aging by regulating the interface between nutrient and hormone cues and cellular growth and maintenance. Among these pathways, the mechanistic target of rapamycin (mTOR) has been most reproducibly shown to modulate aging in evolutionarily diverse organisms as reduction in mTOR activity extends life span from yeast to rodents. mTOR has been shown to play a role in a broad range of diseases, and is of particular interest to human health and aging due to the availability of clinically approved pharmacological agents targeting the mTOR complexes and other components of the mTOR signaling network. Characterizing the role of mTOR in aging and health promises to provide new avenues for intervention in human aging and disease through modulation of this signaling pathway.

Citing Articles

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.

Coleman A, Creevy K, Anderson R, Reed M, Fajt V, Aicher K Geroscience. 2025; .

PMID: 39951177 DOI: 10.1007/s11357-024-01484-7.


Microglial Responses to Alzheimer's Disease Pathology: Insights From "Omics" Studies.

Reid A, Jayadev S, Prater K Glia. 2025; 73(3):519-538.

PMID: 39760224 PMC: 11801359. DOI: 10.1002/glia.24666.


Oleanolic acid improves 5-fluorouracil-induced intestinal damage and inflammation by alleviating intestinal senescence.

Bai S, Zhao B, Zhao Q, Ge Y, Li M, Zhao C Sci Rep. 2024; 14(1):21852.

PMID: 39300121 PMC: 11413160. DOI: 10.1038/s41598-024-72536-3.


Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.

Svensson J, Bolin M, Thor D, Williams P, Brautaset R, Carlsson M BMC Neurol. 2024; 24(1):111.

PMID: 38575854 PMC: 10993488. DOI: 10.1186/s12883-024-03596-1.


Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine.

Song Z, Wang K, Chien Hagar H, Chen H, Kuan C, Zhang K Mol Neurobiol. 2023; 61(5):2653-2671.

PMID: 37919601 PMC: 11043184. DOI: 10.1007/s12035-023-03689-x.