Recent Advances in the Field of Bionanotechnology: an Insight into Optoelectric Bacteriorhodopsin, Quantum Dots, and Noble Metal Nanoclusters

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2014 Oct 24

PMID 25340449

Citations 8

Authors

Christopher Knoblauch

Mark Griep

Craig Friedrich

Affiliations

Soon will be listed here.

Abstract

Molecular sensors and molecular electronics are a major component of a recent research area known as bionanotechnology, which merges biology with nanotechnology. This new class of biosensors and bioelectronics has been a subject of intense research over the past decade and has found application in a wide variety of fields. The unique characteristics of these biomolecular transduction systems has been utilized in applications ranging from solar cells and single-electron transistors (SETs) to fluorescent sensors capable of sensitive and selective detection of a wide variety of targets, both organic and inorganic. This review will discuss three major systems in the area of molecular sensors and electronics and their application in unique technological innovations. Firstly, the synthesis of optoelectric bacteriorhodopsin (bR) and its application in the field of molecular sensors and electronics will be discussed. Next, this article will discuss recent advances in the synthesis and application of semiconductor quantum dots (QDs). Finally, this article will conclude with a review of the new and exciting field of noble metal nanoclusters and their application in the creation of a new class of fluorescent sensors.

Citing Articles

Carbon quantum dots in bioimaging and biomedicines.

Das S, Mondal S, Ghosh D Front Bioeng Biotechnol. 2024; 11:1333752.

PMID: 38318419 PMC: 10841552. DOI: 10.3389/fbioe.2023.1333752.

Small-Molecule Analysis Based on DNA Strand Displacement Using a Bacteriorhodopsin Photoelectric Transducer: Taking ATP as an Example.

Chen H, Wang W, Chen H Sensors (Basel). 2023; 23(17).

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Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential.

Grivard A, Goubet I, Duarte Filho L, Thiery V, Chevalier S, de Oliveira-Junior R Mar Drugs. 2022; 20(8).

PMID: 36005527 PMC: 9410494. DOI: 10.3390/md20080524.

Investigation of spectral and kinetic properties of polymer films based on some analogs of bacteriorhodopsin.

Druzhko A, Pirutin S Eur Biophys J. 2019; 48(8):749-756.

PMID: 31642958 DOI: 10.1007/s00249-019-01401-3.

A Review on Bacteriorhodopsin-Based Bioelectronic Devices.

Li Y, Tian Y, Tian H, Tu T, Gou G, Wang Q Sensors (Basel). 2018; 18(5).

PMID: 29702621 PMC: 5982678. DOI: 10.3390/s18051368.

References

Frigerio C, Ribeiro D, Rodrigues S, Abreu V, Barbosa J, Prior J . Application of quantum dots as analytical tools in automated chemical analysis: a review. Anal Chim Acta. 2012; 735:9-22. DOI: 10.1016/j.aca.2012.04.042. View

Wang Y, Hu R, Lin G, Roy I, Yong K . Functionalized quantum dots for biosensing and bioimaging and concerns on toxicity. ACS Appl Mater Interfaces. 2013; 5(8):2786-99. DOI: 10.1021/am302030a. View

Dennis A, Bao G . Quantum dot-fluorescent protein pairs as novel fluorescence resonance energy transfer probes. Nano Lett. 2008; 8(5):1439-45. DOI: 10.1021/nl080358+. View

Zheng J, Petty J, Dickson R . High quantum yield blue emission from water-soluble Au8 nanodots. J Am Chem Soc. 2003; 125(26):7780-1. DOI: 10.1021/ja035473v. View

Wang C, Xu L, Xu X, Cheng H, Sun H, Lin Q . Near infrared Ag/Au alloy nanoclusters: tunable photoluminescence and cellular imaging. J Colloid Interface Sci. 2013; 416:274-9. DOI: 10.1016/j.jcis.2013.11.011. View

Chan W, Nie S . Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science. 1998; 281(5385):2016-8. DOI: 10.1126/science.281.5385.2016. View

Zhang H, Liu Q, Wang T, Yun Z, Li G, Liu J . Facile preparation of glutathione-stabilized gold nanoclusters for selective determination of chromium (III) and chromium (VI) in environmental water samples. Anal Chim Acta. 2013; 770:140-6. DOI: 10.1016/j.aca.2013.01.042. View

Tao Y, Lin Y, Ren J, Qu X . A dual fluorometric and colorimetric sensor for dopamine based on BSA-stabilized Au nanoclusters. Biosens Bioelectron. 2012; 42:41-6. DOI: 10.1016/j.bios.2012.10.014. View

Kawasaki H, Yoshimura K, Hamaguchi K, Arakawa R . Trypsin-stabilized fluorescent gold nanocluster for sensitive and selective Hg2+ detection. Anal Sci. 2011; 27(6):591-6. DOI: 10.2116/analsci.27.591. View

10.

Alivisatos P . The use of nanocrystals in biological detection. Nat Biotechnol. 2004; 22(1):47-52. DOI: 10.1038/nbt927. View

11.

Falconnet D, Csucs G, Grandin H, Textor M . Surface engineering approaches to micropattern surfaces for cell-based assays. Biomaterials. 2006; 27(16):3044-63. DOI: 10.1016/j.biomaterials.2005.12.024. View

12.

Dacres H, Wang J, Leitch V, Horne I, Anderson A, Trowell S . Greatly enhanced detection of a volatile ligand at femtomolar levels using bioluminescence resonance energy transfer (BRET). Biosens Bioelectron. 2011; 29(1):119-24. DOI: 10.1016/j.bios.2011.08.004. View

13.

Algar W, Tavares A, Krull U . Beyond labels: a review of the application of quantum dots as integrated components of assays, bioprobes, and biosensors utilizing optical transduction. Anal Chim Acta. 2010; 673(1):1-25. DOI: 10.1016/j.aca.2010.05.026. View

14.

Jonas R, Koutalos Y, Ebrey T . Purple membrane: surface charge density and the multiple effect of pH and cations. Photochem Photobiol. 1990; 52(6):1163-77. DOI: 10.1111/j.1751-1097.1990.tb08455.x. View

15.

Anton C, Walczak K, Lueking D, Friedrich C . Integration of optical protein with electronics for bio-nanosensors. J Nanosci Nanotechnol. 2010; 10(9):6104-9. DOI: 10.1166/jnn.2010.2613. View

16.

Xie J, Zheng Y, Ying J . Protein-directed synthesis of highly fluorescent gold nanoclusters. J Am Chem Soc. 2009; 131(3):888-9. DOI: 10.1021/ja806804u. View

17.

Jin H, Choi S, Velu R, Kim S, Lee H . Preparation of multilayered CdSe quantum dot sensitizers by electrostatic layer-by-layer assembly and a series of post-treatments toward efficient quantum dot-sensitized mesoporous TiO2 solar cells. Langmuir. 2012; 28(12):5417-26. DOI: 10.1021/la202892h. View

18.

Freitag S, Le Trong I, Klumb L, Stayton P, Stenkamp R . Structural studies of the streptavidin binding loop. Protein Sci. 1997; 6(6):1157-66. PMC: 2143724. DOI: 10.1002/pro.5560060604. View

19.

Mu X, Qi L, Dong P, Qiao J, Hou J, Nie Z . Facile one-pot synthesis of L-proline-stabilized fluorescent gold nanoclusters and its application as sensing probes for serum iron. Biosens Bioelectron. 2013; 49:249-55. DOI: 10.1016/j.bios.2013.05.019. View

20.

Wang X, Lin R, Xu Z, Huang H, Li L, Liu F . N-acetylcysteine induced quenching of red fluorescent oligonucleotide-stabilized silver nanoclusters and the application in pharmaceutical detection. Anal Chim Acta. 2013; 793:79-85. DOI: 10.1016/j.aca.2013.07.037. View