Septo-hippocampo-septal Loop and Memory Formation

Overview

Journal Basic Clin Neurosci

Specialty Neurology

Date 2014 Oct 23

PMID 25337323

Citations 37

Authors

Fatemeh Khakpai

Mohammad Nasehi

Ali Haeri-Rohani

Akram Eidi

Mohammad Reza Zarrindast

Affiliations

Soon will be listed here.

Abstract

The Cholinergic and GABAergic fibers of the medial septal/diagonal band of Broca (MS/ DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neurons is modulated by several neurotransmitter systems including glutamatergic neurons from the entorhinal cortex, serotonergic fibers from the raphe nucleus, dopaminergic neurons from the ventral tegmental area (VTA), histaminergic cells from the tuberomammillary nucleus and adrenergic fibers from the locus coeruleus (LC). Thus, changes in the glutamatergic, serotonergic and other systems-mediated transmission in the MS/DB may influence cholinergic or GABAergic transmission in the hippocampus.

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References

FLOOD J, Farr S, Uezu K, Morley J . The pharmacology of post-trial memory processing in septum. Eur J Pharmacol. 1998; 350(1):31-8. DOI: 10.1016/s0014-2999(98)00224-6. View

Jafari-Sabet M, Zarrindast M, Rezayat M, Rezayof A, Djahanguiri B . The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice. Life Sci. 2005; 78(2):157-63. DOI: 10.1016/j.lfs.2005.04.040. View

Riedel G, Platt B, Micheau J . Glutamate receptor function in learning and memory. Behav Brain Res. 2003; 140(1-2):1-47. DOI: 10.1016/s0166-4328(02)00272-3. View

Skyers P, Einheber S, Pierce J, Milner T . Increased mu-opioid receptor labeling is found on inner molecular layer terminals of the dentate gyrus following seizures. Exp Neurol. 2003; 179(2):200-9. DOI: 10.1016/s0014-4886(02)00018-3. View

Drever B, Riedel G, Platt B . The cholinergic system and hippocampal plasticity. Behav Brain Res. 2010; 221(2):505-14. DOI: 10.1016/j.bbr.2010.11.037. View

Moor E, deBoer P, Westerink B . GABA receptors and benzodiazepine binding sites modulate hippocampal acetylcholine release in vivo. Eur J Pharmacol. 1998; 359(2-3):119-26. DOI: 10.1016/s0014-2999(98)00642-6. View

Zarrindast M, Moghimi M, Rostami P, Rezayof A . Histaminergic receptors of medial septum and conditioned place preference: D1 dopamine receptor mechanism. Brain Res. 2006; 1109(1):108-16. DOI: 10.1016/j.brainres.2006.06.024. View

Drolet G, Dumont E, Gosselin I, Kinkead R, Laforest S, Trottier J . Role of endogenous opioid system in the regulation of the stress response. Prog Neuropsychopharmacol Biol Psychiatry. 2001; 25(4):729-41. DOI: 10.1016/s0278-5846(01)00161-0. View

Rezayof A, Razavi S, Haeri-Rohani A, Rassouli Y, Zarrindast M . GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference. Eur Neuropsychopharmacol. 2006; 17(1):24-31. DOI: 10.1016/j.euroneuro.2006.02.003. View

10.

Hajos M, Hoffmann W, Orban G, Kiss T, Erdi P . Modulation of septo-hippocampal Theta activity by GABAA receptors: an experimental and computational approach. Neuroscience. 2004; 126(3):599-610. DOI: 10.1016/j.neuroscience.2004.03.043. View

11.

Coussens C, Mason-Parker S, Raymond C, Hargreaves E, Dragunow M, Cohen A . A double dissociation within the hippocampus of dopamine D1/D5 receptor and beta-adrenergic receptor contributions to the persistence of long-term potentiation. Neuroscience. 1999; 92(2):485-97. DOI: 10.1016/s0306-4522(99)00010-x. View

12.

Jackisch R, Gansser S, Cassel J . Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients?. Exp Neurol. 2008; 213(2):345-53. DOI: 10.1016/j.expneurol.2008.06.011. View

13.

Doralp S, Leung L . Cholinergic modulation of hippocampal CA1 basal-dendritic long-term potentiation. Neurobiol Learn Mem. 2008; 90(2):382-8. DOI: 10.1016/j.nlm.2008.05.013. View

14.

Zarrindast M, Homayoun H, Babaie A, Etminani A, Gharib B . Involvement of adrenergic and cholinergic systems in nicotine-induced anxiogenesis in mice. Eur J Pharmacol. 2000; 407(1-2):145-58. DOI: 10.1016/s0014-2999(00)00628-2. View

15.

Romero J, Fernandez-Ruiz J, Vela G, Ruiz-Gayo M, Fuentes J, Ramos J . Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice. Drug Alcohol Depend. 1998; 50(3):241-9. DOI: 10.1016/s0376-8716(98)00036-2. View

16.

Jeltsch-David H, Koenig J, Cassel J . Modulation of cholinergic functions by serotonin and possible implications in memory: general data and focus on 5-HT(1A) receptors of the medial septum. Behav Brain Res. 2008; 195(1):86-97. DOI: 10.1016/j.bbr.2008.02.037. View

17.

Berberich S, Jensen V, Hvalby O, Seeburg P, Kohr G . The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology. 2006; 52(1):77-86. DOI: 10.1016/j.neuropharm.2006.07.016. View

18.

Pourmotabbed A, Motamedi F, Fathollahi Y, Mansouri F, Semnanian S . Involvement of NMDA receptors and voltage-dependent calcium channels on augmentation of long-term potentiation in hippocampal CA1 area of morphine dependent rats. Brain Res. 1998; 804(1):125-34. DOI: 10.1016/s0006-8993(98)00676-3. View

19.

Niewiadomska G, Baksalerska-Pazera M, Riedel G . The septo-hippocampal system, learning and recovery of function. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33(5):791-805. DOI: 10.1016/j.pnpbp.2009.03.039. View

20.

Herman J, Renda A, Bodie B . Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons. Biol Psychiatry. 2003; 53(2):166-74. DOI: 10.1016/s0006-3223(02)01449-x. View