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NK/T Cell Lymphoma Involving Mediastinum: Report of a Case and Review of Literature

Overview
Journal Int J Clin Exp Pathol
Specialty Pathology
Date 2014 Oct 23
PMID 25337299
Citations 3
Authors
Xiang Li
Wei-Hua Liao
Jian-Hua Zhou
Bao-An Liu
Ji-Fang Wen
Zhong-Liang Hu
Affiliations
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Abstract

Extranodal natural killer (NK)/T-cell lymphoma is a very aggressive malignant neoplasia with a poor prognosis. Herein we reported a case of NK/T cell lymphoma involving mediastinum. It was a 28-year-old Chinese male patient. The tumor cells were medium-sized, had irregularly folded nuclei, and inconspicuous or small nucleoli with coagulative necrosis. The tumor cells were positive for CD3ε, TIA-1, but negative for CD56. In situ hybridization revealed that tumor cells also expressed Epstein-Barr virus encoded RNA. To our knowledge, this is the first case of NK/T cell lymphoma involving mediastinum.

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