HLA-DPB1 Variant Effect on Hepatitis B Virus Clearance and Liver Cirrhosis Development Among Southwest Chinese Population

Overview

Journal Hepat Mon

Publisher Brieflands

Specialty Gastroenterology

Date 2014 Oct 23

PMID 25337146

Citations 7

Authors

Zhangyong Hu

Jun Yang

Guolian Xiong

Han Shi

Yuan Yuan

Lin Fan

Yali Wang

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have shown that genetic variants in HLA-DP genes affect disease progression in hepatitis B virus (HBV) infection.

Objectives: We aimed to evaluate possible association between HLA-DPB1 rs9277534 polymorphism and different clinical complications of hepatitis B virus (HBV) infection.

Materials And Methods: Snapshot assay was used to investigate the association of rs9277534 polymorphism in 342 patients with persistent HBV infection and 342 age and gender-matched HBV spontaneous clearance controls. Patients were categorized into asymptomatic HBV carriers (AsC, n = 104), chronic hepatitis B (CHB, n = 116), and liver cirrhosis (LC, n = 122) subgroups.

Results: There was a significantly higher proportion of the rs9277534 minor allele A in HBV spontaneous clearance control than that in HBV persistent infection group (OR = 0.58, 95%CI = 0.46-0.73, P < 0.0001). Genotypic analysis showed that GA and AA genotypes were associated with HBV spontaneous clearance (GA: OR = 0.56, 95%CI = 0.40-0.79, P = 0.019; AA: OR = 0.24, 95%CI = 0.14-0.44, P < 0.0001). A significant difference was found between AsC and LC groups in the distribution of AA genotype (OR = 9.32, 95%CI = 1.293-67.14, P = 0.027).

Conclusions: Variant at rs9277534 could affect both the spontaneous clearance of HBV infection and progression from asymptomatic HBV carriers to HBV-related liver cirrhosis in Southwest Han Chinese population.

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References

Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N . A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet. 2009; 41(5):591-5. DOI: 10.1038/ng.348. View

Zhang Q, Yin J, Zhang Y, Deng Y, Ji X, Du Y . HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations. J Virol. 2013; 87(22):12176-86. PMC: 3807892. DOI: 10.1128/JVI.02073-13. View

Wright T . Introduction to chronic hepatitis B infection. Am J Gastroenterol. 2006; 101 Suppl 1:S1-6. DOI: 10.1111/j.1572-0241.2006.00469.x. View

Thomas R, Thio C, Apps R, Qi Y, Gao X, Marti D . A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. J Virol. 2012; 86(12):6979-85. PMC: 3393572. DOI: 10.1128/JVI.00406-12. View

Hu L, Zhai X, Liu J, Chu M, Pan S, Jiang J . Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development. Hepatology. 2011; 55(5):1426-31. DOI: 10.1002/hep.24799. View

Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N . A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet. 2011; 20(19):3884-92. DOI: 10.1093/hmg/ddr301. View

Cheng H, Liu C, Tseng T, Su T, Yang H, Chen C . Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients. PLoS One. 2013; 8(1):e53008. PMC: 3543438. DOI: 10.1371/journal.pone.0053008. View

Vermehren J, Lotsch J, Susser S, Wicker S, Berger A, Zeuzem S . A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers. PLoS One. 2012; 7(3):e32605. PMC: 3308944. DOI: 10.1371/journal.pone.0032605. View

OBrien T, Kohaar I, Pfeiffer R, Maeder D, Yeager M, Schadt E . Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun. 2011; 12(6):428-33. PMC: 3169805. DOI: 10.1038/gene.2011.11. View

10.

Wong D, Watanabe T, Tanaka Y, Seto W, Lee C, Fung J . Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in Southern Chinese. PLoS One. 2013; 8(6):e66920. PMC: 3692552. DOI: 10.1371/journal.pone.0066920. View

11.

Kim Y, Kim H, Lee J, Yu S, Yoon J, Lee H . A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. Hum Mol Genet. 2013; 22(20):4233-8. DOI: 10.1093/hmg/ddt266. View

12.

Iino S . Natural history of hepatitis B and C virus infections. Oncology. 2002; 62 Suppl 1:18-23. DOI: 10.1159/000048271. View

13.

Webster G, Reignat S, Maini M, Whalley S, Ogg G, King A . Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology. 2000; 32(5):1117-24. DOI: 10.1053/jhep.2000.19324. View

14.

Di Cristofaro J, Silvy M, Chiaroni J, Bailly P . Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use. J Mol Diagn. 2010; 12(4):453-60. PMC: 2893629. DOI: 10.2353/jmoldx.2010.090222. View

15.

Guo X, Zhang Y, Li J, Ma J, Wei Z, Tan W . Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology. 2011; 53(2):422-8. PMC: 3056070. DOI: 10.1002/hep.24048. View

16.

Wang L, Wu X, Zhang W, Zhu D, Wang Y, Li Y . Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies. PLoS One. 2011; 6(3):e17608. PMC: 3050917. DOI: 10.1371/journal.pone.0017608. View

17.

Handunnetthi L, Ramagopalan S, Ebers G, Knight J . Regulation of major histocompatibility complex class II gene expression, genetic variation and disease. Genes Immun. 2009; 11(2):99-112. PMC: 2987717. DOI: 10.1038/gene.2009.83. View

18.

Hirayama K, Chen H, Kikuchi M, Yin T, Gu X, Liu J . HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population. Tissue Antigens. 1999; 53(3):269-74. DOI: 10.1034/j.1399-0039.1999.530307.x. View

19.

Posuwan N, Payungporn S, Tangkijvanich P, Ogawa S, Murakami S, Iijima S . Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population. PLoS One. 2014; 9(1):e86007. PMC: 3900446. DOI: 10.1371/journal.pone.0086007. View

20.

Pieters J . MHC class II-restricted antigen processing and presentation. Adv Immunol. 2000; 75:159-208. DOI: 10.1016/s0065-2776(00)75004-8. View