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» Articles » PMID: 25335696

Isolation, Identification and Characterization of Related Substances in Furbenicillin

Overview
Journal J Antibiot (Tokyo)
Specialties Infectious Diseases
Pharmacology
Date 2014 Oct 23
PMID 25335696
Citations 1
Authors
Ye Tian
Yan Chang
Yan-Chun Feng
Dou-sheng Zhang
Changqin Hu
Affiliations
Soon will be listed here.
Abstract

Furbenicillin is a broad-spectrum semisynthetic penicillin with strong antibacterial activity against Gram-negative bacteria. In this study, three impurities in furbenicillin, including an unknown epimer, were determined. On the basis of a complete analysis of the spectrum (MS, (1)H,(13)C, 2D NMR and CD) and the results of chemical methods, the unknown epimer impurity was identified as 10-epi-furbenicillin (impurity 1). Isolation and structure elucidation of impurity 1 was also reported here for the first time.

Citing Articles

Study on Isomeric Impurities in Cefotiam Hydrochloride.

Tian Y, Chong X, Liu Y, Han Y, Hu C, Yao S Front Chem. 2021; 8:619307.

PMID: 33585401 PMC: 7873999. DOI: 10.3389/fchem.2020.619307.

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