Architects of the Genome: CHD Dysfunction in Cancer, Developmental Disorders and Neurological Syndromes

Overview

Journal Epigenomics

Specialty Genetics

Date 2014 Oct 22

PMID 25333848

Citations 29

Authors

Wangzhi Li

Alea A Mills

Affiliations

Soon will be listed here.

Abstract

Chromatin is vital to normal cells, and its deregulation contributes to a spectrum of human ailments. An emerging concept is that aberrant chromatin regulation culminates in gene expression programs that set the stage for the seemingly diverse pathologies of cancer, developmental disorders and neurological syndromes. However, the mechanisms responsible for such common etiology have been elusive. Recent evidence has implicated lesions affecting chromatin-remodeling proteins in cancer, developmental disorders and neurological syndromes, suggesting a common source for these different pathologies. Here, we focus on the chromodomain helicase DNA binding chromatin-remodeling family and the recent evidence for its deregulation in diverse pathological conditions, providing a new perspective on the underlying mechanisms and their implications for these prevalent human diseases.

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