Dissecting Domain-specific Evolutionary Pressure Profiles of Transient Receptor Potential Vanilloid Subfamily Members 1 to 4

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Oct 22

PMID 25333484

Citations 9

Authors

Pau Donate-Macian

Alex Peralvarez-Marin

Affiliations

Soon will be listed here.

Abstract

The transient receptor potential vanilloid family includes four ion channels-TRPV1, TRPV2, TRPV3 and TRPV4-that are represented within the vertebrate subphylum and involved in several sensory and physiological processes. These channels are related to adaptation to the environment, and probably under strong evolutionary pressure. Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1, TRPV2, TRPV3 and TRPV4. The evolutionary pressure exerted over vertebrate TRPV2 sequences compared to the other channels argues for a positive selection profile for TRPV2 compared to TRPV1, TRPV3 and TRPV4. We have analyzed the selective pressure on specific protein domains, observing a common selective pressure trend for the common TRPV scaffold, consisting of the ankyrin repeat domain, the membrane proximal domain, the transmembrane domain, and the TRP domain. Through a more detailed analysis we have identified evolutionary constraints involved in the subunit contact at the transmembrane domain level. Performing evolutionary comparison, we have translated specific channel structural information such as the transmembrane topology, and the interaction between the membrane proximal domain and the TRP box. We have also identified potential common regulatory domains among all TRPV1-4 members, such as protein-protein, lipid-protein and vesicle trafficking domains.

Citing Articles

Regulation of ThermoTRP Channels by PIP2 and Cholesterol.

Rosenbaum T, Morales-Lazaro S Adv Exp Med Biol. 2023; 1422:245-277.

PMID: 36988884 DOI: 10.1007/978-3-031-21547-6_9.

An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel.

Yang F, Xu L, Lee B, Xiao X, Yarov-Yarovoy V, Zheng J Adv Sci (Weinh). 2020; 7(20):2000575.

PMID: 33101845 PMC: 7578911. DOI: 10.1002/advs.202000575.

Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics.

Donate-Macian P, Enrich-Bengoa J, Degano I, Quintana D, Peralvarez-Marin A Biomolecules. 2019; 9(12).

PMID: 31783610 PMC: 6995547. DOI: 10.3390/biom9120791.

The Membrane Proximal Domain of TRPV1 and TRPV2 Channels Mediates Protein⁻Protein Interactions and Lipid Binding In Vitro.

Donate-Macian P, Alvarez-Marimon E, Sepulcre F, Vazquez-Ibar J, Peralvarez-Marin A Int J Mol Sci. 2019; 20(3).

PMID: 30764505 PMC: 6387362. DOI: 10.3390/ijms20030682.

A TRPV2 interactome-based signature for prognosis in glioblastoma patients.

Donate-Macian P, Gomez A, Degano I, Peralvarez-Marin A Oncotarget. 2018; 9(26):18400-18409.

PMID: 29719613 PMC: 5915080. DOI: 10.18632/oncotarget.24843.

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