β(1-3)(1-6)-D-glucans Modulate Immune Status in Pigs: Potential Importance for Efficiency of Commercial Farming

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2014 Oct 22

PMID 25332992

Citations 18

Authors

Vaclav Vetvicka

Carlos Oliveira

Affiliations

Soon will be listed here.

Abstract

Background: In face of the challenge of the emergent diseases and the current efforts of the governments to create conditions to ban growth-promoting antibiotics and to improve efficiency of the commercial farming, new opportunities are created for natural, highly effective and cost affordable immunomodulators; able to induce and enhance resistance against diseases and to reduce farming-related stress. Supplementation of animal feed with β(1-3)(1-6)-D-glucans has been repeatedly shown to modulate the immune system ant to influence growth characteristics of farmed animals.

Materials And Methods: In our study we focused on evaluation of effects of an insoluble, fungi-derived β(1-3)(1-6)-D-glucan as dietary supplement in piglets. We measured the growth, phagocytosis of peripheral blood cells and interleukin 2 (IL-2) and tumor necrosis factor alpha (TNF-α) production after feeding with 15 mg of glucan/kg/day.

Conclusions: Following supplementation, β(1-3)(1-6)-D-glucan has been shown to stimulate growth, phagocytic activity, and IL-2 production. In addition, it significantly lowered the cortisol and TNF-α levels after lipopolysaccharide (LPS) challenge.

Citing Articles

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Applications of Probiotic-Based Multi-Components to Human, Animal and Ecosystem Health: Concepts, Methodologies, and Action Mechanisms.

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Zhen W, Liu Y, Shao Y, Ma Y, Wu Y, Guo F Front Microbiol. 2022; 12:766878.

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Donovan B, Suarez-Trujillo A, Casey T, Aryal U, Conklin D, Williams L Animals (Basel). 2021; 11(2).

PMID: 33672799 PMC: 7918739. DOI: 10.3390/ani11020497.

References

Borchers A, Stern J, HACKMAN R, Keen C, Gershwin M . Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999; 221(4):281-93. DOI: 10.1046/j.1525-1373.1999.d01-86.x. View

Dritz S, Shi J, Kielian T, Goodband R, Nelssen J, Tokach M . Influence of dietary beta-glucan on growth performance, nonspecific immunity, and resistance to Streptococcus suis infection in weanling pigs. J Anim Sci. 1995; 73(11):3341-50. DOI: 10.2527/1995.73113341x. View

Stuyven E, Cox E, Vancaeneghem S, Arnouts S, Deprez P, Goddeeris B . Effect of beta-glucans on an ETEC infection in piglets. Vet Immunol Immunopathol. 2008; 128(1-3):60-6. DOI: 10.1016/j.vetimm.2008.10.311. View

Jiang Z, Sun L, Lin Y, Ma X, Zheng C, Zhou G . Effects of dietary glycyl-glutamine on growth performance, small intestinal integrity, and immune responses of weaning piglets challenged with lipopolysaccharide. J Anim Sci. 2009; 87(12):4050-6. DOI: 10.2527/jas.2008-1120. View

Du Pasquier L . The immune system of invertebrates and vertebrates. Comp Biochem Physiol B Biochem Mol Biol. 2001; 129(1):1-15. DOI: 10.1016/s1096-4959(01)00306-2. View

Lambert G . Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects. J Anim Sci. 2008; 87(14 Suppl):E101-8. DOI: 10.2527/jas.2008-1339. View

Vetvicka V, Fornusek L, Kopecek J, Kaminkova J, KASPAREK L, Vranova M . Phagocytosis of human blood leukocytes: a simple micromethod. Immunol Lett. 1982; 5(2):97-100. DOI: 10.1016/0165-2478(82)90040-2. View

Dong J, Cai F, Shen R, Liu Y . Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice. Food Chem. 2014; 129(3):1066-71. DOI: 10.1016/j.foodchem.2011.05.076. View

Ewaschuk J, Johnson I, Madsen K, Vasanthan T, Ball R, Field C . Barley-derived β-glucans increases gut permeability, ex vivo epithelial cell binding to E. coli, and naive T-cell proportions in weanling pigs. J Anim Sci. 2012; 90(8):2652-62. DOI: 10.2527/jas.2011-4381. View

10.

Eicher S, McKee C, Carroll J, Pajor E . Supplemental vitamin C and yeast cell wall beta-glucan as growth enhancers in newborn pigs and as immunomodulators after an endotoxin challenge after weaning. J Anim Sci. 2006; 84(9):2352-60. DOI: 10.2527/jas.2005-770. View

11.

Vetvicka V, Holub M, Kovaru H, Siman P, Kovaru F . Alpha-fetoprotein and phagocytosis in athymic nude mice. Immunol Lett. 1988; 19(2):95-8. DOI: 10.1016/0165-2478(88)90125-3. View

12.

Chen K, Weng B, Chang M, Liao Y, Chen T, Chu C . Direct enhancement of the phagocytic and bactericidal capability of abdominal macrophage of chicks by beta-1,3-1,6-glucan. Poult Sci. 2008; 87(11):2242-9. DOI: 10.3382/ps.2008-00147. View

13.

Welker T, Lim C, Yildirim-Aksoy M, Klesius P . Effect of short-term feeding duration of diets containing commercial whole-cell yeast or yeast subcomponents on immune function and disease resistance in channel catfish, Ictalurus punctatus. J Anim Physiol Anim Nutr (Berl). 2011; 96(2):159-71. DOI: 10.1111/j.1439-0396.2011.01127.x. View

14.

Hester S, Comstock S, Thorum S, Monaco M, Pence B, Woods J . Intestinal and systemic immune development and response to vaccination are unaffected by dietary (1,3/1,6)-β-D-glucan supplementation in neonatal piglets. Clin Vaccine Immunol. 2012; 19(9):1499-508. PMC: 3428409. DOI: 10.1128/CVI.00338-12. View

15.

Murphy P, Dal Bello F, ODoherty J, Arendt E, Sweeney T, Coffey A . Effects of cereal β-glucans and enzyme inclusion on the porcine gastrointestinal tract microbiota. Anaerobe. 2012; 18(6):557-65. DOI: 10.1016/j.anaerobe.2012.09.005. View

16.

Hiss S, Sauerwein H . Influence of dietary ss-glucan on growth performance, lymphocyte proliferation, specific immune response and haptoglobin plasma concentrations in pigs. J Anim Physiol Anim Nutr (Berl). 2003; 87(1-2):2-11. DOI: 10.1046/j.1439-0396.2003.00376.x. View

17.

Magnadottir B . Innate immunity of fish (overview). Fish Shellfish Immunol. 2005; 20(2):137-51. DOI: 10.1016/j.fsi.2004.09.006. View

18.

Vetvicka V, Vancikova Z . Anti-stress action of several orally-given β-glucans. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010; 154(3):235-8. DOI: 10.5507/bp.2010.035. View

19.

Li J, Li D, Xing J, Cheng Z, Lai C . Effects of beta-glucan extracted from Saccharomyces cerevisiae on growth performance, and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopolysaccharide. J Anim Sci. 2006; 84(9):2374-81. DOI: 10.2527/jas.2004-541. View

20.

Cho J, Zhang Z, Kim I . Effects of single or combined dietary supplementation of β-glucan and kefir on growth performance, blood characteristics and meat quality in broilers. Br Poult Sci. 2013; 54(2):216-21. DOI: 10.1080/00071668.2013.777691. View