Establishment and Assessment of New Formulas for Energy Consumption Estimation in Adult Burn Patients

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Oct 21

PMID 25330180

Citations 4

Authors

Peng Xi

Wang Kaifa

Zhang Yong

Yan Hong

Wang Chao

Song Lijuan

Wang Hongyu

Wu Dan

Jiang Hua

Wang Shiliang

Affiliations

Soon will be listed here.

Abstract

Objective: An accurate knowledge of energy consumption in burn patients is a prerequisite for rational nutrition therapy. This study sought to create a formula that accounts for the metabolic characteristics of adult burn patients to accurately estimate energy consumption of patients with different areas and extents of burn and at different times after injury.

Methods: Resting energy expenditure (REE) data on 66 burn patients, with total body surface area (TBSA) of burns ranging from 4% to 96%, were evaluated at different times after injury. REE values were determined in patients using indirect calorimetry at days 1, 2, 3, 7, 14, 21, and 28 after injury. We then constructed a mathematical model of REE changes post-burn. Next, established two new formulas (one non-linear and the other linear) for energy consumption estimation using model-based analytical solution and regression analysis. The new formulas were compared with measured REE and commonly used formulas including those of Carlson, Xie, Curreri, and Milner to determine accuracy and reliability.

Results: Comparative analysis showed that the new formulas offered significantly higher accuracy and reliability than the Milner formula, which is considered the most accurate of commonly used burn energy consumption estimate formulas. The accuracy of the new nonlinear formula (94.29%) and that of the linear formula (91.43%) were significantly higher than that of Milner formula (72.86%) when compared to measured REE (χ2 = 11.706, P = 0.001; χ2 = 8.230, P = 0.004, respectively). The reliabilities of the new estimation formulas were both 100% and that of Milner formula was 74.24% (χ2 = 19.513, P = 0.000).

Conclusion: The new formulas constructed in this study provide reliable simulation of the impact of the degree of burn and post-burn days on energy consumption and offer notably higher accuracy and reliability than other formulas. These formulas will help determine nutritional needs of burn patients.

Trial Registration: The study was registered on Chinese Clinical Trial Registry as ChiCTR-TRC-13003806.

Citing Articles

Nutritional therapy among adult patients with severe burns: A retrospective observational study.

Fu J, Cui W, Sheng B Asia Pac J Clin Nutr. 2024; 33(4):496-502.

PMID: 39209359 PMC: 11389804. DOI: 10.6133/apjcn.202412_33(4).0004.

Effects of early exercise training following severe burn injury: a randomized controlled trial.

Schieffelers D, Ru T, Dai H, Ye Z, van Breda E, Daele U Burns Trauma. 2024; 12:tkae005.

PMID: 38716050 PMC: 11075770. DOI: 10.1093/burnst/tkae005.

[Application and research progress of permissive hypocaloric nutrition in nutritional therapy of severe burns].

Fang H, Xia Z Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023; 39(7):685-689.

PMID: 37805699 PMC: 11630171. DOI: 10.3760/cma.j.cn501225-20221010-00445.

[Strengthening the development and application of precision burn medicine].

Luo G, Sun X, Wu J Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023; 39(7):612-617.

PMID: 37805689 PMC: 11630206. DOI: 10.3760/cma.j.cn501225-20230407-00116.

Current understanding of the chronic stress response to burn injury from human studies.

Osborne T, Wall B, Edgar D, Fairchild T, Wood F Burns Trauma. 2023; 11:tkad007.

PMID: 36926636 PMC: 10013650. DOI: 10.1093/burnst/tkad007.

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