Impact of Exercise and Moderate Hypoxia on Glycemic Regulation and Substrate Oxidation Pattern

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Oct 21

PMID 25329405

Citations 19

Authors

Takuma Morishima

Ayaka Mori

Hiroto Sasaki

Kazushige Goto

Affiliations

Soon will be listed here.

Abstract

Objective: We examined metabolic and endocrine responses during rest and exercise in moderate hypoxia over a 7.5 h time courses during daytime.

Methods: Eight sedentary, overweight men (28.6 ± 0.8 kg/m2) completed four experimental trials: a rest trial in normoxia (FiO2 = 20.9%, NOR-Rest), an exercise trial in normoxia (NOR-Ex), a rest trial in hypoxia (FiO2 = 15.0%, HYP-Rest), and an exercise trial in hypoxia (HYP-Ex). Experimental trials were performed from 8:00 to 15:30 in an environmental chamber. Blood and respiratory gas samples were collected over 7.5 h. In the exercise trials, subjects performed 30 min of pedaling exercise at 60% of VO2max at 8:00, 10:30, and 13:00, and rested during the remaining period in each environment. Standard meals were provided at 8:30, 11:00, and 13:30.

Results: The areas under the curves for blood glucose and serum insulin concentrations over 7.5 h did not differ among the four trials. At baseline, %carbohydrate contribution was significantly higher in the hypoxic trials than in the normoxic trials (P<0.05). Although exercise promoted carbohydrate oxidation in the NOR-Ex and HYP-Ex trials, %carbohydrate contribution during each exercise and post-exercise period were significantly higher in the HYP-Ex trial than in the NOR-Ex trial (P<0.05).

Conclusion: Three sessions of 30 min exercise (60% of VO2max) in moderate hypoxia over 7.5 h did not attenuate postprandial glucose and insulin responses in young, overweight men. However, carbohydrate oxidation was significantly enhanced when the exercise was conducted in moderate hypoxia.

Citing Articles

Effects of exercise modality combined with moderate hypoxia on blood glucose regulation in adults with overweight.

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Mechanisms for Combined Hypoxic Conditioning and Divergent Exercise Modes to Regulate Inflammation, Body Composition, Appetite, and Blood Glucose Homeostasis in Overweight and Obese Adults: A Narrative Review.

Tee C, Cooke M, Chong M, Yeo W, Camera D Sports Med. 2022; 53(2):327-348.

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Is Physical Exercise in Hypoxia an Interesting Strategy to Prevent the Development of Type 2 Diabetes? A Narrative Review.

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van Meijel R, Vogel M, Jocken J, Vliex L, Smeets J, Hoebers N Mol Metab. 2021; 53:101287.

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The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: A systematic review.

van Hulten V, van Meijel R, Goossens G Rev Endocr Metab Disord. 2021; 22(2):471-483.

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